Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2311535..2312173 Replicon chromosome
Accession NZ_CP114130
Organism Escherichia coli strain NJS001

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N0F11_RS11495 Protein ID WP_000813794.1
Coordinates 2311535..2311711 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N0F11_RS11500 Protein ID WP_001270286.1
Coordinates 2311757..2312173 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0F11_RS11475 (2307157) 2307157..2308329 - 1173 WP_250844899.1 BenE family transporter YdcO -
N0F11_RS11480 (2308421) 2308421..2308957 + 537 WP_000429145.1 DNA-binding transcriptional regulator SutR -
N0F11_RS11485 (2309030) 2309030..2310991 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N0F11_RS11490 (2311083) 2311083..2311313 - 231 WP_000494244.1 YncJ family protein -
N0F11_RS11495 (2311535) 2311535..2311711 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N0F11_RS11500 (2311757) 2311757..2312173 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N0F11_RS11505 (2312252) 2312252..2313658 + 1407 WP_000760654.1 PLP-dependent aminotransferase family protein -
N0F11_RS11510 (2313903) 2313903..2315048 + 1146 WP_000047432.1 ABC transporter substrate-binding protein -
N0F11_RS11515 (2315066) 2315066..2316079 + 1014 WP_000220402.1 ABC transporter ATP-binding protein -
N0F11_RS11520 (2316080) 2316080..2317021 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T266302 WP_000813794.1 NZ_CP114130:2311535-2311711 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT266302 WP_001270286.1 NZ_CP114130:2311757-2312173 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References