Detailed information of TA system TA026630

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2141015..2141544
• Replicon: chromosome
• Accession: NC_017340
• Organism: Staphylococcus aureus 04-02981

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: SA2981_RS10850
• Protein ID: WP_000621175.1
• Coordinates: 2141015..2141377 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: SA2981_RS10855
• Protein ID: WP_000948331.1
• Coordinates: 2141374..2141544 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SA2981_RS10825	2137993..2138763	-	771	WP_001041111.1	RNA polymerase sigma factor SigB	-
SA2981_RS10830	2138738..2139217	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
SA2981_RS10835	2139219..2139545	-	327	WP_001052491.1	anti-sigma factor antagonist	-
SA2981_RS10840	2139664..2140665	-	1002	WP_000390827.1	PP2C family protein-serine/threonine phosphatase	-
SA2981_RS10850	2141015..2141377	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
SA2981_RS10855	2141374..2141544	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
SA2981_RS10860	2141629..2142777	-	1149	WP_001281154.1	alanine racemase	-
SA2981_RS10865	2142843..2143202	-	360	WP_000581197.1	holo-ACP synthase	-
SA2981_RS10870	2143206..2143697	-	492	WP_001205912.1	PH domain-containing protein	-
SA2981_RS10875	2143684..2145267	-	1584	WP_001294626.1	PH domain-containing protein	-
SA2981_RS10880	2145260..2145739	-	480	WP_001287087.1	hypothetical protein	-
SA2981_RS10885	2145947..2146507	-	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T26630 WP_000621175.1 NC_017340:c2141377-2141015 [Staphylococcus aureus 04-02981]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T26630 NC_017340:c2141377-2141015 [Staphylococcus aureus 04-02981]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT26630 WP_000948331.1 NC_017340:c2141544-2141374 [Staphylococcus aureus 04-02981]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT26630 NC_017340:c2141544-2141374 [Staphylococcus aureus 04-02981]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1