Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 890651..891305 Replicon chromosome
Accession NZ_CP114130
Organism Escherichia coli strain NJS001

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag N0F11_RS04445 Protein ID WP_000244781.1
Coordinates 890898..891305 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag N0F11_RS04440 Protein ID WP_000354046.1
Coordinates 890651..890917 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0F11_RS04420 (886739) 886739..888172 - 1434 WP_001310226.1 6-phospho-beta-glucosidase BglA -
N0F11_RS04425 (888217) 888217..888528 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
N0F11_RS04430 (888692) 888692..889351 + 660 WP_000250274.1 hemolysin III family protein -
N0F11_RS04435 (889428) 889428..890408 - 981 WP_000886053.1 tRNA-modifying protein YgfZ -
N0F11_RS04440 (890651) 890651..890917 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
N0F11_RS04445 (890898) 890898..891305 + 408 WP_000244781.1 protein YgfX Toxin
N0F11_RS04450 (891345) 891345..891866 - 522 WP_001055874.1 flavodoxin FldB -
N0F11_RS04455 (891978) 891978..892874 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
N0F11_RS04460 (892899) 892899..893609 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
N0F11_RS04465 (893615) 893615..895348 + 1734 WP_000813185.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T266292 WP_000244781.1 NZ_CP114130:890898-891305 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT266292 WP_000354046.1 NZ_CP114130:890651-890917 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References