Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 309874..310505 Replicon chromosome
Accession NZ_CP114130
Organism Escherichia coli strain NJS001

Toxin (Protein)


Gene name hicA Uniprot ID Q8X5S6
Locus tag N0F11_RS01460 Protein ID WP_001259386.1
Coordinates 309874..310149 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag N0F11_RS01465 Protein ID WP_000593555.1
Coordinates 310146..310505 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0F11_RS01445 (304878) 304878..305945 + 1068 WP_000361458.1 HlyD family secretion protein -
N0F11_RS01450 (305942) 305942..308677 + 2736 WP_000149107.1 ribosome-associated ATPase/putative transporter RbbA -
N0F11_RS01455 (308677) 308677..309801 + 1125 WP_001301659.1 ABC transporter permease -
N0F11_RS01460 (309874) 309874..310149 + 276 WP_001259386.1 type II toxin-antitoxin system HicA family toxin Toxin
N0F11_RS01465 (310146) 310146..310505 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N0F11_RS01470 (310555) 310555..311415 - 861 WP_001131788.1 class II aldolase -
N0F11_RS01475 (311447) 311447..311716 - 270 WP_000933060.1 HPr family phosphocarrier protein -
N0F11_RS01480 (311706) 311706..313214 - 1509 WP_085562190.1 FGGY-family carbohydrate kinase -
N0F11_RS01485 (313207) 313207..314565 - 1359 WP_001302220.1 PTS galactitol transporter subunit IIC -
N0F11_RS01490 (314642) 314642..314923 - 282 WP_000084025.1 PTS sugar transporter subunit IIB -
N0F11_RS01495 (314920) 314920..315393 - 474 WP_001161553.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 299582..310505 10923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10165.92 Da        Isoelectric Point: 10.7076

>T266287 WP_001259386.1 NZ_CP114130:309874-310149 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKLILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT266287 WP_000593555.1 NZ_CP114130:310146-310505 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I9WXY7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References