Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4530168..4530665 Replicon chromosome
Accession NZ_CP114128
Organism Escherichia coli strain PE164

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag LZG51_RS22215 Protein ID WP_001173343.1
Coordinates 4530168..4530341 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag LZG51_RS22220 Protein ID WP_000398619.1
Coordinates 4530369..4530665 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG51_RS22205 (4526838) 4526838..4528295 + 1458 WP_000856824.1 dipeptide/tripeptide permease DtpC -
LZG51_RS22210 (4528532) 4528532..4530049 + 1518 WP_001295065.1 lysine--tRNA ligase -
LZG51_RS22215 (4530168) 4530168..4530341 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
LZG51_RS22220 (4530369) 4530369..4530665 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
LZG51_RS22225 (4530892) 4530892..4531164 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
LZG51_RS22230 (4531176) 4531176..4531406 - 231 WP_089553482.1 4Fe-4S mono-cluster protein YjdI -
LZG51_RS22235 (4531587) 4531587..4533218 + 1632 WP_001216477.1 sensor histidine kinase -
LZG51_RS22240 (4533215) 4533215..4533934 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - escG / escF / cesD2 / espB / espD / espA / sepL / escD / eae / cesT / tir / map / cesF / espH / sepQ/escQ / escO / escN / escV / cesL / sepZ/espZ / escI / escJ / sepD / escC / cesD / etgA / escU / escT / escS / escR / escL / escK / cesAB / escE / espG / efa1 4472110..4530665 58555


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T266285 WP_001173343.1 NZ_CP114128:c4530341-4530168 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT266285 WP_000398619.1 NZ_CP114128:c4530665-4530369 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References