Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4168879..4169429 Replicon chromosome
Accession NZ_CP114128
Organism Escherichia coli strain PE164

Toxin (Protein)


Gene name ccdB Uniprot ID D3H432
Locus tag LZG51_RS20365 Protein ID WP_001160975.1
Coordinates 4168879..4169193 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag LZG51_RS20370 Protein ID WP_000125567.1
Coordinates 4169196..4169429 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG51_RS20340 (4164554) 4164554..4165840 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
LZG51_RS20345 (4165840) 4165840..4166829 + 990 WP_053883425.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
LZG51_RS20350 (4166826) 4166826..4167647 + 822 WP_096220318.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
LZG51_RS20355 (4167650) 4167650..4168027 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
LZG51_RS20360 (4168034) 4168034..4168882 + 849 WP_000257188.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
LZG51_RS20365 (4168879) 4168879..4169193 - 315 WP_001160975.1 CcdB family protein Toxin
LZG51_RS20370 (4169196) 4169196..4169429 - 234 WP_000125567.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LZG51_RS20375 (4169515) 4169515..4169994 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
LZG51_RS20380 (4170186) 4170186..4172048 - 1863 WP_000377117.1 glutathione-regulated potassium-efflux system protein KefC -
LZG51_RS20385 (4172041) 4172041..4172571 - 531 WP_000600718.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
LZG51_RS20390 (4172682) 4172682..4174013 - 1332 WP_001183198.1 MFS transporter -
LZG51_RS20395 (4174072) 4174072..4174359 - 288 WP_000203741.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.76 Da        Isoelectric Point: 9.8517

>T266284 WP_001160975.1 NZ_CP114128:c4169193-4168879 [Escherichia coli]
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8544.55 Da        Isoelectric Point: 5.8147

>AT266284 WP_000125567.1 NZ_CP114128:c4169429-4169196 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSEEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References