Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3719324..3719942 Replicon chromosome
Accession NZ_CP114128
Organism Escherichia coli strain PE164

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LZG51_RS18230 Protein ID WP_001291435.1
Coordinates 3719724..3719942 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LZG51_RS18225 Protein ID WP_000344800.1
Coordinates 3719324..3719698 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG51_RS18215 (3714413) 3714413..3715606 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LZG51_RS18220 (3715629) 3715629..3718778 + 3150 WP_053883285.1 efflux RND transporter permease AcrB -
LZG51_RS18225 (3719324) 3719324..3719698 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LZG51_RS18230 (3719724) 3719724..3719942 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LZG51_RS18235 (3720114) 3720114..3720665 + 552 WP_096220366.1 maltose O-acetyltransferase -
LZG51_RS18240 (3720781) 3720781..3721251 + 471 WP_000136192.1 YlaC family protein -
LZG51_RS18245 (3721415) 3721415..3722965 + 1551 WP_053883318.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LZG51_RS18250 (3723007) 3723007..3723360 - 354 WP_000878140.1 DUF1428 domain-containing protein -
LZG51_RS18260 (3723739) 3723739..3724050 + 312 WP_000409911.1 MGMT family protein -
LZG51_RS18265 (3724081) 3724081..3724653 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T266282 WP_001291435.1 NZ_CP114128:3719724-3719942 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT266282 WP_000344800.1 NZ_CP114128:3719324-3719698 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References