Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2481284..2481922 Replicon chromosome
Accession NZ_CP114128
Organism Escherichia coli strain PE164

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag LZG51_RS12035 Protein ID WP_000813794.1
Coordinates 2481284..2481460 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LZG51_RS12040 Protein ID WP_001270286.1
Coordinates 2481506..2481922 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG51_RS12015 (2476903) 2476903..2478078 - 1176 WP_053883748.1 BenE family transporter YdcO -
LZG51_RS12020 (2478170) 2478170..2478706 + 537 WP_000429150.1 DNA-binding transcriptional regulator SutR -
LZG51_RS12025 (2478779) 2478779..2480740 + 1962 WP_207184267.1 U32 family peptidase -
LZG51_RS12030 (2480832) 2480832..2481062 - 231 WP_000494244.1 YncJ family protein -
LZG51_RS12035 (2481284) 2481284..2481460 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LZG51_RS12040 (2481506) 2481506..2481922 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LZG51_RS12045 (2482001) 2482001..2483410 + 1410 WP_000760625.1 PLP-dependent aminotransferase family protein -
LZG51_RS12050 (2483652) 2483652..2484797 + 1146 WP_089637768.1 ABC transporter substrate-binding protein -
LZG51_RS12055 (2484815) 2484815..2485828 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
LZG51_RS12060 (2485829) 2485829..2486770 + 942 WP_053883752.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T266275 WP_000813794.1 NZ_CP114128:2481284-2481460 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT266275 WP_001270286.1 NZ_CP114128:2481506-2481922 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References