Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1873963..1874553 Replicon chromosome
Accession NZ_CP114128
Organism Escherichia coli strain PE164

Toxin (Protein)


Gene name pemK Uniprot ID A0A8S7CSP3
Locus tag LZG51_RS08900 Protein ID WP_053884197.1
Coordinates 1874221..1874553 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A8S7CTL7
Locus tag LZG51_RS08895 Protein ID WP_053884198.1
Coordinates 1873963..1874220 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG51_RS08880 (1870975) 1870975..1872579 + 1605 WP_089553513.1 LA2681 family HEPN domain-containing protein -
LZG51_RS08885 (1872950) 1872950..1873411 + 462 WP_000201268.1 hypothetical protein -
LZG51_RS08890 (1873408) 1873408..1873614 + 207 WP_053884199.1 helix-turn-helix transcriptional regulator -
LZG51_RS08895 (1873963) 1873963..1874220 + 258 WP_053884198.1 antitoxin Antitoxin
LZG51_RS08900 (1874221) 1874221..1874553 + 333 WP_053884197.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LZG51_RS08905 (1875403) 1875403..1876287 + 885 WP_053884196.1 integrase domain-containing protein -
LZG51_RS08910 (1876561) 1876561..1876872 + 312 WP_064763322.1 hypothetical protein -
LZG51_RS08915 (1876859) 1876859..1877215 + 357 WP_053884194.1 IS66 family insertion sequence element accessory protein TnpB -
LZG51_RS08920 (1877222) 1877222..1878760 + 1539 WP_053884193.1 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1851773..1927672 75899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11807.53 Da        Isoelectric Point: 9.3417

>T266272 WP_053884197.1 NZ_CP114128:1874221-1874553 [Escherichia coli]
MDRGEIWLVSLDPTTGHEQSGKRPVLIVSKASFNTFTRLPVVVPVTSGGNFAREAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARSGKRLERIPDAVVNEVLARLEAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9281.74 Da        Isoelectric Point: 4.4488

>AT266272 WP_053884198.1 NZ_CP114128:1873963-1874220 [Escherichia coli]
MYTTRLKKVGGSVMLAVPPAVLKTLGLSTDSEVGMTIDDGCLIIEPQKRPRYSLEELLAQCDPHAEISEEGREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References