Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 850738..851392 Replicon chromosome
Accession NZ_CP114128
Organism Escherichia coli strain PE164

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag LZG51_RS04120 Protein ID WP_000244777.1
Coordinates 850985..851392 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag LZG51_RS04115 Protein ID WP_000354046.1
Coordinates 850738..851004 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG51_RS04095 (846708) 846708..848141 - 1434 WP_053883955.1 6-phospho-beta-glucosidase BglA -
LZG51_RS04100 (848186) 848186..848497 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
LZG51_RS04105 (848661) 848661..849320 + 660 WP_053883911.1 hemolysin III family protein -
LZG51_RS04110 (849515) 849515..850495 - 981 WP_053883913.1 tRNA-modifying protein YgfZ -
LZG51_RS04115 (850738) 850738..851004 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
LZG51_RS04120 (850985) 850985..851392 + 408 WP_000244777.1 protein YgfX Toxin
LZG51_RS04125 (851432) 851432..851953 - 522 WP_001055874.1 flavodoxin FldB -
LZG51_RS04130 (852065) 852065..852961 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
LZG51_RS04135 (852986) 852986..853696 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LZG51_RS04140 (853702) 853702..855435 + 1734 WP_000813168.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T266269 WP_000244777.1 NZ_CP114128:850985-851392 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT266269 WP_000354046.1 NZ_CP114128:850738-851004 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References