Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 307972..308772 Replicon chromosome
Accession NZ_CP114128
Organism Escherichia coli strain PE164

Toxin (Protein)


Gene name ataT Uniprot ID A0A0K4AFE4
Locus tag LZG51_RS01385 Protein ID WP_001614005.1
Coordinates 308245..308772 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A8S7FBC9
Locus tag LZG51_RS01380 Protein ID WP_053883614.1
Coordinates 307972..308238 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG51_RS01360 (303630) 303630..304298 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
LZG51_RS01365 (304291) 304291..305349 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
LZG51_RS01370 (305594) 305594..306448 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
LZG51_RS01375 (306719) 306719..307822 + 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
LZG51_RS01380 (307972) 307972..308238 + 267 WP_053883614.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
LZG51_RS01385 (308245) 308245..308772 + 528 WP_001614005.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
LZG51_RS01390 (308769) 308769..309152 - 384 WP_000778770.1 aspartate 1-decarboxylase autocleavage activator PanM -
LZG51_RS01395 (309576) 309576..310685 + 1110 WP_001301528.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
LZG51_RS01400 (310733) 310733..311659 + 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LZG51_RS01405 (311656) 311656..312933 + 1278 WP_001626130.1 branched chain amino acid ABC transporter permease LivM -
LZG51_RS01410 (312930) 312930..313697 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19676.62 Da        Isoelectric Point: 7.3502

>T266266 WP_001614005.1 NZ_CP114128:308245-308772 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYKSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9940.40 Da        Isoelectric Point: 10.0863

>AT266266 WP_053883614.1 NZ_CP114128:307972-308238 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWMRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4AFE4

Antitoxin

Source ID Structure

References