Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 286297..286883 Replicon chromosome
Accession NZ_CP114128
Organism Escherichia coli strain PE164

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag LZG51_RS01255 Protein ID WP_042014162.1
Coordinates 286297..286527 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag LZG51_RS01260 Protein ID WP_000593555.1
Coordinates 286524..286883 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG51_RS01245 (282334) 282334..285069 + 2736 WP_053883606.1 ribosome-associated ATPase/putative transporter RbbA -
LZG51_RS01250 (285069) 285069..286193 + 1125 WP_001216257.1 ABC transporter permease -
LZG51_RS01255 (286297) 286297..286527 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
LZG51_RS01260 (286524) 286524..286883 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LZG51_RS01265 (287003) 287003..287404 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
LZG51_RS01270 (287410) 287410..288216 - 807 WP_053883607.1 nickel import ATP-binding protein NikE -
LZG51_RS01275 (288213) 288213..288977 - 765 WP_089637315.1 nickel import ATP-binding protein NikD -
LZG51_RS01280 (288977) 288977..289810 - 834 WP_096220430.1 nickel ABC transporter permease subunit NikC -
LZG51_RS01285 (289807) 289807..290751 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T266265 WP_042014162.1 NZ_CP114128:286297-286527 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT266265 WP_000593555.1 NZ_CP114128:286524-286883 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References