Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 2919786..2920399 Replicon chromosome
Accession NZ_CP114115
Organism Pseudomonas sp. GXZC

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A1YYQ4
Locus tag OZ428_RS13950 Protein ID WP_038846635.1
Coordinates 2920148..2920399 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OZ428_RS13945 Protein ID WP_269133768.1
Coordinates 2919786..2920151 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OZ428_RS13930 (OZ428_13930) 2916620..2917192 + 573 WP_269133765.1 DUF2239 family protein -
OZ428_RS13935 (OZ428_13935) 2917218..2918573 + 1356 WP_269133766.1 MATE family efflux transporter -
OZ428_RS13940 (OZ428_13940) 2918613..2919785 + 1173 WP_269133767.1 MFS transporter -
OZ428_RS13945 (OZ428_13945) 2919786..2920151 - 366 WP_269133768.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OZ428_RS13950 (OZ428_13950) 2920148..2920399 - 252 WP_038846635.1 type II toxin-antitoxin system HicA family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9518.11 Da        Isoelectric Point: 10.0459

>T266257 WP_038846635.1 NZ_CP114115:c2920399-2920148 [Pseudomonas sp. GXZC]
VSKNEKLLAKLLNEHMAFTWPELVTLLRRLGYTQIEGAGSRVKFDIGDPSAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13178.97 Da        Isoelectric Point: 6.7403

>AT266257 WP_269133768.1 NZ_CP114115:c2920151-2919786 [Pseudomonas sp. GXZC]
VNNQLKHKGYIGSIEASVEDNCLFGKILFIKALVSYEGKTVAELDAAFREAVDDYLATCQTLGHTPEKPCKGSFNVRVGH
DLHLAAALAATRKKVTLNDLTRQALNEFLQHHSDDACPAIG

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1YYQ4

Antitoxin

Source ID Structure

References