Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2196352..2196956 Replicon chromosome
Accession NZ_CP114115
Organism Pseudomonas sp. GXZC

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OZ428_RS10530 Protein ID WP_269133324.1
Coordinates 2196352..2196540 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OZ428_RS10535 Protein ID WP_269133325.1
Coordinates 2196552..2196956 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OZ428_RS10505 (OZ428_10505) 2192071..2192643 + 573 WP_269133319.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
OZ428_RS10510 (OZ428_10510) 2192634..2193383 + 750 WP_269133320.1 phosphonate metabolism protein PhnP -
OZ428_RS10515 (OZ428_10515) 2193403..2194098 - 696 WP_269133321.1 helix-turn-helix transcriptional regulator -
OZ428_RS10520 (OZ428_10520) 2194173..2195294 + 1122 WP_269133322.1 cytochrome P450 -
OZ428_RS10525 (OZ428_10525) 2195280..2196161 - 882 WP_269133323.1 LysR family transcriptional regulator -
OZ428_RS10530 (OZ428_10530) 2196352..2196540 + 189 WP_269133324.1 type II toxin-antitoxin system HicA family toxin Toxin
OZ428_RS10535 (OZ428_10535) 2196552..2196956 + 405 WP_269133325.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OZ428_RS10540 (OZ428_10540) 2197262..2198803 + 1542 WP_269133326.1 M10 family metallopeptidase C-terminal domain-containing protein -
OZ428_RS10545 (OZ428_10545) 2198813..2200009 - 1197 WP_095015309.1 MFS transporter -
OZ428_RS10550 (OZ428_10550) 2200181..2200795 + 615 WP_269133327.1 DUF5666 domain-containing protein -
OZ428_RS10555 (OZ428_10555) 2200925..2201929 - 1005 WP_016979582.1 sulfate ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7139.35 Da        Isoelectric Point: 10.5621

>T266255 WP_269133324.1 NZ_CP114115:2196352-2196540 [Pseudomonas sp. GXZC]
VQSRLLIKELQEAGWVLDRVTGSHHIFTHCYSPYTLPVPHPKKDLPLGTVRSIRKRAGLFQF

Download         Length: 189 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14773.74 Da        Isoelectric Point: 4.4999

>AT266255 WP_269133325.1 NZ_CP114115:2196552-2196956 [Pseudomonas sp. GXZC]
MQYPICIEWGDDFTATGIQIPDIPGAVTAGDSFEEAYNAAVEIAHIMLQEIAAEGGPIPMPTSVANHHAHEDYADMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRS

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References