Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1377165..1378081 Replicon chromosome
Accession NZ_CP114066
Organism Bacillus halotolerans strain B13

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag O0R52_RS06910 Protein ID WP_044156223.1
Coordinates 1377335..1378081 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A7G7U9Y3
Locus tag O0R52_RS06905 Protein ID WP_024121090.1
Coordinates 1377165..1377335 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O0R52_RS06870 (O0R52_06870) 1374029..1374358 + 330 WP_044156231.1 XkdW family protein -
O0R52_RS06875 (O0R52_06875) 1374355..1374519 + 165 WP_044156230.1 XkdX family protein -
O0R52_RS06880 (O0R52_06880) 1374563..1375402 + 840 WP_044156229.1 hypothetical protein -
O0R52_RS06885 (O0R52_06885) 1375458..1375727 + 270 WP_044156228.1 hemolysin XhlA family protein -
O0R52_RS06890 (O0R52_06890) 1375739..1376002 + 264 WP_044156226.1 phage holin -
O0R52_RS06895 (O0R52_06895) 1376015..1376908 + 894 WP_217827104.1 N-acetylmuramoyl-L-alanine amidase -
O0R52_RS06900 (O0R52_06900) 1376944..1377081 - 138 WP_125825426.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
O0R52_RS06905 (O0R52_06905) 1377165..1377335 - 171 WP_024121090.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
O0R52_RS06910 (O0R52_06910) 1377335..1378081 - 747 WP_044156223.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
O0R52_RS06915 (O0R52_06915) 1378190..1379191 - 1002 WP_044156221.1 inorganic phosphate transporter -
O0R52_RS06920 (O0R52_06920) 1379204..1379821 - 618 WP_044156219.1 DUF47 domain-containing protein -
O0R52_RS06925 (O0R52_06925) 1380100..1381416 - 1317 WP_044156218.1 serine/threonine exchanger -
O0R52_RS06930 (O0R52_06930) 1381811..1382761 + 951 WP_059292934.1 ring-cleaving dioxygenase -
O0R52_RS06935 (O0R52_06935) 1382927..1383007 + 81 Protein_1302 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29102.52 Da        Isoelectric Point: 4.4373

>T266249 WP_044156223.1 NZ_CP114066:c1378081-1377335 [Bacillus halotolerans]
MLLFFQIMVWCTMAALGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMIYWTYDPSSLFTNWERYVIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLDRLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CYYSTQSDKDRLTEHMEDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6578.62 Da        Isoelectric Point: 10.9236

>AT266249 WP_024121090.1 NZ_CP114066:c1377335-1377165 [Bacillus halotolerans]
MENAFQNGCHPRAKKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7G7U9Y3

References