Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4693910..4694472 Replicon chromosome
Accession NZ_CP114065
Organism Kribbella sp. CA-293567

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OX958_RS21490 Protein ID WP_270130895.1
Coordinates 4694161..4694472 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag OX958_RS21485 Protein ID WP_270130893.1
Coordinates 4693910..4694161 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OX958_RS21460 (OX958_21495) 4689912..4691225 - 1314 WP_270130887.1 histidinol dehydrogenase -
OX958_RS21465 (OX958_21500) 4691349..4692017 + 669 WP_270130888.1 LON peptidase substrate-binding domain-containing protein -
OX958_RS21470 (OX958_21505) 4692019..4692402 + 384 WP_270130889.1 hypothetical protein -
OX958_RS21475 (OX958_21510) 4692454..4693290 + 837 WP_270130890.1 metalloregulator ArsR/SmtB family transcription factor -
OX958_RS21480 (OX958_21515) 4693287..4693877 + 591 WP_270130891.1 dihydrofolate reductase family protein -
OX958_RS21485 (OX958_21520) 4693910..4694161 + 252 WP_270130893.1 ribbon-helix-helix domain-containing protein Antitoxin
OX958_RS21490 (OX958_21525) 4694161..4694472 + 312 WP_270130895.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OX958_RS21495 (OX958_21530) 4694478..4696328 - 1851 WP_270130897.1 dihydroxy-acid dehydratase -
OX958_RS21500 (OX958_21535) 4696467..4697309 + 843 WP_270130899.1 helix-turn-helix domain-containing protein -
OX958_RS21505 (OX958_21540) 4697306..4697743 + 438 WP_270130901.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11255.22 Da        Isoelectric Point: 7.1661

>T266247 WP_270130895.1 NZ_CP114065:4694161-4694472 [Kribbella sp. CA-293567]
MRPLHIARLDKPRPVVVLTRELIRPRLTNVTVAPITSTIRGLSTEVLVGVRNGLDHPSAISCDNVQTIPKLQLGRLIGYL
LPDQEAALAEAITLAFDLEADLL

Download         Length: 312 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9165.25 Da        Isoelectric Point: 4.3398

>AT266247 WP_270130893.1 NZ_CP114065:4693910-4694161 [Kribbella sp. CA-293567]
MSKQITVRLPDELVEFMDRLVDDNKASSRASVVARAMERERRRELAERDAAILEAHSLAAREDPDDLDGLAVTAGGTVLT
DLD

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References