266245

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3045804..3046420 Replicon chromosome
Accession NZ_CP114062
Organism Rouxiella badensis strain DAR84756

Toxin (Protein)


Gene name Hha Uniprot ID A0A1X0WJL4
Locus tag O1V65_RS14120 Protein ID WP_026110585.1
Coordinates 3046217..3046420 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1X0WJ85
Locus tag O1V65_RS14115 Protein ID WP_017492280.1
Coordinates 3045804..3046172 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1V65_RS14085 (O1V65_14080) 3041766..3042020 + 255 WP_009639086.1 type B 50S ribosomal protein L31 -
O1V65_RS14090 (O1V65_14085) 3042041..3042181 + 141 WP_009639085.1 type B 50S ribosomal protein L36 -
O1V65_RS14095 (O1V65_14090) 3042314..3043192 - 879 WP_017492284.1 metal ABC transporter substrate-binding protein -
O1V65_RS14100 (O1V65_14095) 3043229..3044086 - 858 WP_017492283.1 metal ABC transporter permease -
O1V65_RS14105 (O1V65_14100) 3044083..3044820 - 738 WP_017492282.1 ABC transporter ATP-binding protein -
O1V65_RS14110 (O1V65_14105) 3045250..3045603 + 354 WP_017492281.1 hypothetical protein -
O1V65_RS14115 (O1V65_14110) 3045804..3046172 + 369 WP_017492280.1 Hha toxicity modulator TomB Antitoxin
O1V65_RS14120 (O1V65_14115) 3046217..3046420 + 204 WP_026110585.1 HHA domain-containing protein Toxin
O1V65_RS14125 (O1V65_14120) 3046599..3047525 - 927 WP_017492278.1 LysR family transcriptional regulator -
O1V65_RS14130 (O1V65_14125) 3047669..3049456 + 1788 WP_165429737.1 adenine deaminase C-terminal domain-containing protein -
O1V65_RS14135 (O1V65_14130) 3049521..3050870 + 1350 WP_269129821.1 NCS2 family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8115.43 Da        Isoelectric Point: 7.9892

>T266245 WP_026110585.1 NZ_CP114062:3046217-3046420 [Rouxiella badensis]
MNKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELELFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14280.97 Da        Isoelectric Point: 4.5844

>AT266245 WP_017492280.1 NZ_CP114062:3045804-3046172 [Rouxiella badensis]
MDEYSPKRHDIAQLRFLNESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDETNLSDLVEEYL
DDTYTLFSNYGINDSDLRQWQKTKKRLFRMFSGDYVCTLMKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X0WJL4

Antitoxin

Source ID Structure
AlphaFold DB A0A1X0WJ85

References