Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1257797..1258456 Replicon chromosome
Accession NZ_CP114062
Organism Rouxiella badensis strain DAR84756

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag O1V65_RS06080 Protein ID WP_017491644.1
Coordinates 1258268..1258456 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag O1V65_RS06075 Protein ID WP_017491645.1
Coordinates 1257797..1258204 (-) Length 136 a.a.

Genomic Context

O1V65_RS06035O1V65_RS06040O1V65_RS06045O1V65_RS06055O1V65_RS06060O1V65_RS06065O1V65_RS06070O1V65_RS06085O1V65_RS06090O1V65_RS06095O1V65_RS06100O1V65_RS06105O1V65_RS06110O1V65_RS06115O1V65_RS06120O1V65_RS06125O1V65_RS06050O1V65_RS06075O1V65_RS06080
Location: 1252918..1253520 (603 bp)
Type: Others
Protein ID: WP_269130286.1
Location: 1253517..1253759 (243 bp)
Type: Others
Protein ID: WP_017491647.1
Location: 1253845..1254612 (768 bp)
Type: Others
Protein ID: WP_269130287.1
Location: 1255347..1255514 (168 bp)
Type: Others
Protein ID: WP_269130289.1
Location: 1255587..1256474 (888 bp)
Type: Others
Protein ID: WP_269130290.1
Location: 1256554..1257345 (792 bp)
Type: Others
Protein ID: WP_269130291.1
Location: 1257342..1257578 (237 bp)
Type: Others
Protein ID: WP_269130292.1
Location: 1258640..1259281 (642 bp)
Type: Others
Protein ID: WP_017491643.1
Location: 1259262..1260215 (954 bp)
Type: Others
Protein ID: WP_269130293.1
Location: 1260352..1260666 (315 bp)
Type: Others
Protein ID: WP_017491641.1
Location: 1260666..1261160 (495 bp)
Type: Others
Protein ID: WP_269130294.1
Location: 1261264..1261683 (420 bp)
Type: Others
Protein ID: WP_269130296.1
Location: 1261791..1261994 (204 bp)
Type: Others
Protein ID: WP_269130297.1
Location: 1262075..1262422 (348 bp)
Type: Others
Protein ID: WP_269130298.1
Location: 1262522..1262755 (234 bp)
Type: Others
Protein ID: WP_269130299.1
Location: 1262806..1263042 (237 bp)
Type: Others
Protein ID: WP_269130300.1
Location: 1254786..1255226 (441 bp)
Type: Others
Protein ID: WP_269130288.1
Location: 1257797..1258204 (408 bp)
Type: Antitoxin
Protein ID: WP_017491645.1
Location: 1258268..1258456 (189 bp)
Type: Toxin
Protein ID: WP_017491644.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
O1V65_RS06035 (O1V65_06030)1252918..1253520+603WP_269130286.1recombination protein NinG-
O1V65_RS06040 (O1V65_06035)1253517..1253759+243WP_017491647.1hypothetical protein-
O1V65_RS06045 (O1V65_06040)1253845..1254612+768WP_269130287.1antitermination protein-
O1V65_RS06050 (O1V65_06045)1254786..1255226-441WP_269130288.1Arc family DNA-binding protein-
O1V65_RS06055 (O1V65_06050)1255347..1255514+168WP_269130289.1Arc family DNA binding domain-containing protein-
O1V65_RS06060 (O1V65_06055)1255587..1256474+888WP_269130290.1phage antirepressor N-terminal domain-containing protein-
O1V65_RS06065 (O1V65_06060)1256554..1257345+792WP_269130291.1ORF6N domain-containing protein-
O1V65_RS06070 (O1V65_06065)1257342..1257578+237WP_269130292.1hypothetical protein-
O1V65_RS06075 (O1V65_06070)1257797..1258204-408WP_017491645.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
O1V65_RS06080 (O1V65_06075)1258268..1258456-189WP_017491644.1type II toxin-antitoxin system HicA family toxinToxin
O1V65_RS06085 (O1V65_06080)1258640..1259281+642WP_017491643.1hypothetical protein-
O1V65_RS06090 (O1V65_06085)1259262..1260215+954WP_269130293.1glycosyltransferase family 1 protein-
O1V65_RS06095 (O1V65_06090)1260352..1260666+315WP_017491641.1hypothetical protein-
O1V65_RS06100 (O1V65_06095)1260666..1261160+495WP_269130294.1lysozyme-
O1V65_RS06105 (O1V65_06100)1261264..1261683+420WP_269130296.1hypothetical protein-
O1V65_RS06110 (O1V65_06105)1261791..1261994+204WP_269130297.1hypothetical protein-
O1V65_RS06115 (O1V65_06110)1262075..1262422+348WP_269130298.1hypothetical protein-
O1V65_RS06120 (O1V65_06115)1262522..1262755+234WP_269130299.1hypothetical protein-
O1V65_RS06125 (O1V65_06120)1262806..1263042+237WP_269130300.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1235062..128512550063


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7135.33 Da        Isoelectric Point: 10.9194

>T266239 WP_017491644.1 NZ_CP114062:c1258456-1258268 [Rouxiella badensis]
MQSRELIKLLEADGWKEVGRSGSHRTFSKEGVREIITIPHPRKDTSKGILRQVQKYTGMKLL

Download         Length: 189 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14882.74 Da        Isoelectric Point: 4.3708

>AT266239 WP_017491645.1 NZ_CP114062:c1258204-1257797 [Rouxiella badensis]
MIYPIFIFKSESGFDGYFPDVPGCFFSGDTLEDAVKDSEAAFGAHCDVLTERGDHVPAPADVSAYLGDERLIEDGGFLGF
VEIDPTKYESKAVKFNLTMPSNLIAAIDRFIEKNGQYKNRSAFLAELARKEIARG

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References