Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 856110..856587 Replicon chromosome
Accession NC_017340
Organism Staphylococcus aureus 04-02981

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SA2981_RS04120 Protein ID WP_000052076.1
Coordinates 856110..856298 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SA2981_RS04125 Protein ID WP_001059690.1
Coordinates 856327..856587 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA2981_RS04090 852104..852625 + 522 WP_000824482.1 hypothetical protein -
SA2981_RS04095 852966..853652 + 687 WP_000141557.1 thermonuclease family protein -
SA2981_RS04100 854009..854209 + 201 WP_001059082.1 cold-shock protein -
SA2981_RS04105 854701..854919 - 219 WP_000005886.1 hypothetical protein -
SA2981_RS04110 854981..855265 - 285 WP_001004399.1 hypothetical protein -
SA2981_RS04115 855353..855922 - 570 WP_001106658.1 hypothetical protein -
SA2981_RS04120 856110..856298 - 189 WP_000052076.1 hypothetical protein Toxin
SA2981_RS04125 856327..856587 - 261 WP_001059690.1 hypothetical protein Antitoxin
SA2981_RS04130 856928..857131 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SA2981_RS04135 857128..857364 - 237 WP_000349581.1 hypothetical protein -
SA2981_RS04140 857589..858170 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
SA2981_RS04145 858243..858860 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
SA2981_RS04150 859015..859509 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SA2981_RS04155 859908..860330 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SA2981_RS04160 860478..861194 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-70)

Antitoxin

Toxin YoeB

(5-84)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T26623 WP_000052076.1 NC_017340:c856298-856110 [Staphylococcus aureus 04-02981]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T26623 NC_017340:c856298-856110 [Staphylococcus aureus 04-02981]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT26623 WP_001059690.1 NC_017340:c856587-856327 [Staphylococcus aureus 04-02981]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT26623 NC_017340:c856587-856327 [Staphylococcus aureus 04-02981]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References