Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 1924799..1925288 Replicon chromosome
Accession NZ_CP114053
Organism Bifidobacterium longum subsp. infantis strain Y46

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag O0R44_RS08740 Protein ID WP_229773994.1
Coordinates 1924799..1925026 (-) Length 76 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A4V2N072
Locus tag O0R44_RS08745 Protein ID WP_032744823.1
Coordinates 1925052..1925288 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O0R44_RS08725 (O0R44_08725) 1922022..1922744 - 723 WP_032744819.1 hypothetical protein -
O0R44_RS08730 (O0R44_08730) 1922809..1923765 - 957 WP_032744820.1 A/G-specific adenine glycosylase -
O0R44_RS08735 (O0R44_08735) 1923786..1924448 + 663 WP_136527151.1 tRNA (cytidine(34)-2'-O)-methyltransferase -
O0R44_RS08740 (O0R44_08740) 1924799..1925026 - 228 WP_229773994.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O0R44_RS08745 (O0R44_08745) 1925052..1925288 - 237 WP_032744823.1 ribbon-helix-helix domain-containing protein Antitoxin
O0R44_RS08750 (O0R44_08750) 1925871..1926512 - 642 WP_192575730.1 4'-phosphopantetheinyl transferase superfamily protein -
O0R44_RS08755 (O0R44_08755) 1926595..1927920 - 1326 WP_230581269.1 MFS transporter -
O0R44_RS08760 (O0R44_08760) 1927947..1929134 - 1188 WP_032744825.1 carboxylate--amine ligase -
O0R44_RS08765 (O0R44_08765) 1929136..1929735 - 600 WP_269136706.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1924799..1937932 13133


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-72)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8653.22 Da        Isoelectric Point: 10.1818

>T266229 WP_229773994.1 NZ_CP114053:c1925026-1924799 [Bifidobacterium longum subsp. infantis]
MKKLDRNVAKRIIAKLREISQLEDPRSTGKALAGNLAGLWRYRVGDYRIVCDIEDEVLLILVIDVAHRSKVYKRC

Download         Length: 228 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8928.15 Da        Isoelectric Point: 4.2821

>AT266229 WP_032744823.1 NZ_CP114053:c1925288-1925052 [Bifidobacterium longum subsp. infantis]
MATVTAALRMPVELAARYDCLAKATGRTKTFYMNEALTESIDRFEYEYGIMKKVEDWRAGRLETVTLDELEESLGLED

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4V2N072

References