Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/RelB(antitoxin)
Location 1466625..1467264 Replicon chromosome
Accession NZ_CP114053
Organism Bifidobacterium longum subsp. infantis strain Y46

Toxin (Protein)


Gene name mazF Uniprot ID W6EZW1
Locus tag O0R44_RS06725 Protein ID WP_014484977.1
Coordinates 1466908..1467264 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag O0R44_RS06720 Protein ID WP_003829235.1
Coordinates 1466625..1466921 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O0R44_RS06695 (O0R44_06695) 1462016..1464694 - 2679 WP_032743694.1 alanine--tRNA ligase -
O0R44_RS06700 (O0R44_06700) 1464823..1465059 - 237 WP_007053386.1 hypothetical protein -
O0R44_RS06705 (O0R44_06705) 1465059..1465457 - 399 WP_032743693.1 DUF948 domain-containing protein -
O0R44_RS06710 (O0R44_06710) 1465540..1466214 - 675 WP_032743692.1 histidine phosphatase family protein -
O0R44_RS06715 (O0R44_06715) 1466289..1466555 + 267 WP_230581180.1 hypothetical protein -
O0R44_RS06720 (O0R44_06720) 1466625..1466921 + 297 WP_003829235.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
O0R44_RS06725 (O0R44_06725) 1466908..1467264 + 357 WP_014484977.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
O0R44_RS06730 (O0R44_06730) 1467539..1468141 - 603 WP_032743691.1 transglutaminase family protein -
O0R44_RS06735 (O0R44_06735) 1468246..1468611 - 366 WP_269136689.1 SdpI family protein -
O0R44_RS06740 (O0R44_06740) 1468496..1468885 + 390 WP_230581178.1 cytidine deaminase -
O0R44_RS06745 (O0R44_06745) 1469023..1469805 + 783 WP_032743690.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
O0R44_RS06750 (O0R44_06750) 1469984..1470610 - 627 WP_007052130.1 30S ribosomal protein S4 -
O0R44_RS06755 (O0R44_06755) 1470809..1471801 - 993 WP_080714690.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-111)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(12-54)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13302.25 Da        Isoelectric Point: 8.9603

>T266227 WP_014484977.1 NZ_CP114053:1466908-1467264 [Bifidobacterium longum subsp. infantis]
MMKTDPRQFEIWWVPFAFPDKPGKAKNRPSVILQWDDGTRIALVTKVTGNTWRDEPGYVVLRDWQDAGLSKPSAVRCSQL
LRLPSNLFLDDGPTGRLSAYDAGRVAWAINELYPGLLA

Download         Length: 357 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10997.50 Da        Isoelectric Point: 4.2896

>AT266227 WP_003829235.1 NZ_CP114053:1466625-1466921 [Bifidobacterium longum subsp. infantis]
MMAIKEKTTISLDAQTKRDGIAILDAMGLNLSTFAEMSLRQLVRDGRLPFTPSVRPSFEKDNEGYPLFKANMDDPRIVTP
QIRDGAVILPEGWDDDED

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L7D489

Antitoxin

Source ID Structure

References