Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 1058887..1059740 Replicon chromosome
Accession NZ_CP114053
Organism Bifidobacterium longum subsp. infantis strain Y46

Toxin (Protein)


Gene name relE Uniprot ID A0A7D5BU34
Locus tag O0R44_RS04645 Protein ID WP_032745209.1
Coordinates 1059249..1059740 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q8G4I4
Locus tag O0R44_RS04640 Protein ID WP_011068030.1
Coordinates 1058887..1059249 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O0R44_RS04635 (O0R44_04635) 1056042..1058741 + 2700 WP_032745210.1 aconitate hydratase AcnA -
O0R44_RS04640 (O0R44_04640) 1058887..1059249 + 363 WP_011068030.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
O0R44_RS04645 (O0R44_04645) 1059249..1059740 + 492 WP_032745209.1 PIN domain-containing protein Toxin
O0R44_RS04650 (O0R44_04650) 1059801..1061905 - 2105 Protein_899 DUF262 domain-containing protein -
O0R44_RS04655 (O0R44_04655) 1061994..1062635 - 642 WP_032745208.1 GNAT family N-acetyltransferase -
O0R44_RS04660 (O0R44_04660) 1062676..1062816 - 141 Protein_901 LuxR C-terminal-related transcriptional regulator -
O0R44_RS04665 (O0R44_04665) 1062985..1063887 + 903 WP_032745207.1 Bax inhibitor-1/YccA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-141)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18298.86 Da        Isoelectric Point: 4.5590

>T266226 WP_032745209.1 NZ_CP114053:1059249-1059740 [Bifidobacterium longum subsp. infantis]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLSSSAIRRECKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCRTPAEIVA
ALE

Download         Length: 492 bp

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 14004.05 Da        Isoelectric Point: 5.0733

>AT266226 WP_011068030.1 NZ_CP114053:1058887-1059249 [Bifidobacterium longum subsp. infantis]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDTYYNMKRAD

Download         Length: 363 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D5BU34

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2W1N3

References