Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 970035..970618 Replicon chromosome
Accession NZ_CP114053
Organism Bifidobacterium longum subsp. infantis strain Y46

Toxin (Protein)


Gene name PumA Uniprot ID A0A1S2VZ23
Locus tag O0R44_RS04290 Protein ID WP_032745284.1
Coordinates 970316..970618 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID I3AVV5
Locus tag O0R44_RS04285 Protein ID WP_007057517.1
Coordinates 970035..970319 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O0R44_RS04260 (O0R44_04260) 966179..966547 - 369 WP_155270629.1 hypothetical protein -
O0R44_RS04265 (O0R44_04265) 966541..967623 + 1083 Protein_822 transposase -
O0R44_RS04270 (O0R44_04270) 967721..968629 + 909 WP_032744304.1 ABC transporter ATP-binding protein -
O0R44_RS04275 (O0R44_04275) 968626..969357 + 732 WP_032744305.1 ABC transporter permease -
O0R44_RS04280 (O0R44_04280) 969375..969926 - 552 Protein_825 IS30 family transposase -
O0R44_RS04285 (O0R44_04285) 970035..970319 - 285 WP_007057517.1 putative addiction module antidote protein Antitoxin
O0R44_RS04290 (O0R44_04290) 970316..970618 - 303 WP_032745284.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O0R44_RS04295 (O0R44_04295) 970656..971090 - 435 WP_230581286.1 DUF1922 domain-containing protein -
O0R44_RS04300 (O0R44_04300) 971111..971599 + 489 WP_032745281.1 D-aminoacyl-tRNA deacylase -
O0R44_RS04305 (O0R44_04305) 971760..974879 + 3120 WP_136527129.1 alpha-mannosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 969375..969830 455


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(9-92)

Antitoxin

Uncharacterized protein HI1420

(3-92)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11350.08 Da        Isoelectric Point: 10.4626

>T266225 WP_032745284.1 NZ_CP114053:c970618-970316 [Bifidobacterium longum subsp. infantis]
IKQSAEYRKWFKKLRDHKAKAAIQARLDACKLAGRPFGDIKPVGGPVSEMRFHTGAGYRVYFAMQGNVLMLLLAGGDKST
QQTDIRQAHDILNDYKEQRQ

Download         Length: 303 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10158.37 Da        Isoelectric Point: 4.3707

>AT266225 WP_007057517.1 NZ_CP114053:c970319-970035 [Bifidobacterium longum subsp. infantis]
MSTEFTDYDTSEYLENEQDIIAYLNAIAEYDDPALMQAALGNVAKARGMTQIAKDAGVGRESLYKSLSKDGNPSFQTIAK
VIHALGGRLTIQAA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S2VZ23

Antitoxin

Source ID Structure
AlphaFold DB I3AVV5

References