Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 3749060..3749631 Replicon chromosome
Accession NZ_CP114036
Organism Streptomyces sp. S465

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag N6H00_RS15830 Protein ID WP_268972343.1
Coordinates 3749060..3749434 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag N6H00_RS15835 Protein ID WP_268972344.1
Coordinates 3749434..3749631 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6H00_RS15815 (N6H00_15815) 3744930..3745715 - 786 WP_268972340.1 S16 family serine protease -
N6H00_RS15820 (N6H00_15820) 3746159..3746800 - 642 WP_268972341.1 helix-turn-helix domain-containing protein -
N6H00_RS15825 (N6H00_15825) 3747153..3748949 - 1797 WP_268972342.1 DEAD/DEAH box helicase -
N6H00_RS15830 (N6H00_15830) 3749060..3749434 - 375 WP_268972343.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
N6H00_RS15835 (N6H00_15835) 3749434..3749631 - 198 WP_268972344.1 Arc family DNA-binding protein Antitoxin
N6H00_RS15840 (N6H00_15840) 3749665..3751116 - 1452 WP_268972345.1 MFS transporter -
N6H00_RS15845 (N6H00_15845) 3751398..3752369 - 972 WP_268976985.1 putative sulfate exporter family transporter -
N6H00_RS15850 (N6H00_15850) 3752450..3753019 - 570 WP_268972346.1 cysteine dioxygenase family protein -
N6H00_RS15855 (N6H00_15855) 3753136..3754041 - 906 WP_268972347.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(12-119)

Antitoxin

Arc-like DNA binding domain

(4-45)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13866.73 Da        Isoelectric Point: 4.7156

>T266221 WP_268972343.1 NZ_CP114036:c3749434-3749060 [Streptomyces sp. S465]
MHYLTLPELLHLAERLGESEVRDYGLLESALARPQASVFGQDAYPDVWQKAAALMESLARNHALVDGNKRLSWYATWVFL
HINGHPLDAAFDVDEAERFVLGVCQGELDVPKIAEGLTRFTNGM

Download         Length: 375 bp

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7365.31 Da        Isoelectric Point: 6.2185

>AT266221 WP_268972344.1 NZ_CP114036:c3749631-3749434 [Streptomyces sp. S465]
MAALNLRFTDEELEALRKRAEAEGRSMQSFAHDAVMAAINEHSRLFNEAAAHVLRVSEELNRRLA

Download         Length: 198 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References