Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 3870330..3871213 Replicon chromosome
Accession NZ_CP114035
Organism Pseudomonas putida strain GMI12077

Toxin (Protein)


Gene name - Uniprot ID R9VG37
Locus tag OZ911_RS17630 Protein ID WP_016487683.1
Coordinates 3870330..3870767 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R9VFG2
Locus tag OZ911_RS17635 Protein ID WP_016487684.1
Coordinates 3870764..3871213 (-) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OZ911_RS17605 (OZ911_17605) 3865824..3866216 - 393 WP_031311787.1 hypothetical protein -
OZ911_RS17610 (OZ911_17610) 3866209..3866589 - 381 WP_023047359.1 hypothetical protein -
OZ911_RS17615 (OZ911_17615) 3866678..3867907 - 1230 WP_016487680.1 acyl-CoA dehydrogenase -
OZ911_RS17620 (OZ911_17620) 3868047..3868973 + 927 WP_016487681.1 LysR family transcriptional regulator -
OZ911_RS17625 (OZ911_17625) 3869168..3870322 + 1155 WP_016487682.1 aminotransferase class V-fold PLP-dependent enzyme -
OZ911_RS17630 (OZ911_17630) 3870330..3870767 - 438 WP_016487683.1 RES family NAD+ phosphorylase Toxin
OZ911_RS17635 (OZ911_17635) 3870764..3871213 - 450 WP_016487684.1 MbcA/ParS/Xre antitoxin family protein Antitoxin
OZ911_RS17640 (OZ911_17640) 3871320..3872096 - 777 WP_016487685.1 SDR family oxidoreductase -
OZ911_RS17645 (OZ911_17645) 3872240..3873160 - 921 WP_016487686.1 LysR family transcriptional regulator -
OZ911_RS17650 (OZ911_17650) 3873453..3874175 - 723 WP_023047356.1 hypothetical protein -
OZ911_RS17655 (OZ911_17655) 3874255..3874554 - 300 WP_016487688.1 DUF3077 domain-containing protein -
OZ911_RS17660 (OZ911_17660) 3874754..3875377 + 624 WP_023047355.1 glutathione S-transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-138)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(33-91)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 16005.35 Da        Isoelectric Point: 6.2187

>T266217 WP_016487683.1 NZ_CP114035:c3870767-3870330 [Pseudomonas putida]
VILWRISAYADLSGTGGLRVSGRWHQAGRPVVYAATSPSGAMLEVLVHLEIDPEDFPTTMRLIRIELPDTVSQAQLPALQ
PGWSAQPELTRALGNRFLDDCSALLLPVPSAIMPSTINYLFNPRHAQAQRAKIQVEDFTPDSRLF

Download         Length: 438 bp

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 17096.64 Da        Isoelectric Point: 6.1089

>AT266217 WP_016487684.1 NZ_CP114035:c3871213-3870764 [Pseudomonas putida]
MLAEVLRDNGYHEYRARLQALLEIPELASDFEIHTRITHGFAATWLVKLTERGVFTPVERDQIIPLRTLKTRIERDQPLT
VEESDRLFRSAHITAMAEAVFGEADKAKRWLSKPKERFSGLTPMQMLTTQQGTTQVEEMLLQIAEGFGL

Download         Length: 450 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R9VG37

Antitoxin

Source ID Structure
AlphaFold DB R9VFG2

References