Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 5370394..5371029 Replicon chromosome
Accession NZ_CP114031
Organism Paenibacillus thiaminolyticus strain PATH554

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag O0V01_RS24260 Protein ID WP_087444735.1
Coordinates 5370394..5370744 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2W4HCL7
Locus tag O0V01_RS24265 Protein ID WP_040731899.1
Coordinates 5370748..5371029 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O0V01_RS24250 (O0V01_24265) 5367408..5368310 + 903 WP_284655322.1 hypothetical protein -
O0V01_RS24255 (O0V01_24270) 5368273..5369877 + 1605 WP_284655323.1 M60 family metallopeptidase -
O0V01_RS24260 (O0V01_24275) 5370394..5370744 - 351 WP_087444735.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
O0V01_RS24265 (O0V01_24280) 5370748..5371029 - 282 WP_040731899.1 CopG family ribbon-helix-helix protein Antitoxin
O0V01_RS24270 (O0V01_24285) 5371280..5372473 - 1194 WP_284655325.1 alanine racemase -
O0V01_RS24275 (O0V01_24290) 5372715..5373833 - 1119 WP_284655326.1 DUF4367 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12862.87 Da        Isoelectric Point: 5.6312

>T266216 WP_087444735.1 NZ_CP114031:c5370744-5370394 [Paenibacillus thiaminolyticus]
MIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKTHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMRKVDDGLLISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10735.45 Da        Isoelectric Point: 8.4934

>AT266216 WP_040731899.1 NZ_CP114031:c5371029-5370748 [Paenibacillus thiaminolyticus]
VANIQNTKRIMISLPDQLLQEVDGIVAMEKSNRSEFIRQAMKLYLQERKKRHIRESMQRGYMEMAKINLTMASEAFYAEV
EADGTLDRLVSGV

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2W4HCL7

References