Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 1002398..1002972 Replicon chromosome
Accession NZ_CP113980
Organism Listeria newyorkensis strain CMB191063

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag OTR81_RS04910 Protein ID WP_036090226.1
Coordinates 1002634..1002972 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A3N9TRL1
Locus tag OTR81_RS04905 Protein ID WP_036090223.1
Coordinates 1002398..1002640 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OTR81_RS04880 (OTR81_06660) 997417..998523 - 1107 WP_036090213.1 PTS fructose transporter subunit IIC -
OTR81_RS04885 (OTR81_06655) 998536..998856 - 321 WP_036060685.1 PTS fructose transporter subunit IIB -
OTR81_RS04890 (OTR81_06650) 998853..999317 - 465 WP_036090216.1 PTS sugar transporter subunit IIA -
OTR81_RS04895 (OTR81_06645) 999317..1001272 - 1956 WP_036090218.1 BglG family transcription antiterminator -
OTR81_RS04900 (OTR81_06640) 1001430..1002287 + 858 WP_036090220.1 GRP family sugar transporter -
OTR81_RS04905 (OTR81_06635) 1002398..1002640 + 243 WP_036090223.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
OTR81_RS04910 (OTR81_06630) 1002634..1002972 + 339 WP_036090226.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OTR81_RS04915 (OTR81_06625) 1003484..1003855 - 372 WP_036090230.1 hypothetical protein -
OTR81_RS04920 (OTR81_16070) 1004092..1004196 + 105 WP_112859886.1 type I toxin-antitoxin system Fst family toxin -
OTR81_RS04925 (OTR81_06620) 1004501..1006045 - 1545 WP_036090232.1 gluconokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-105)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12796.78 Da        Isoelectric Point: 9.7794

>T266208 WP_036090226.1 NZ_CP113980:1002634-1002972 [Listeria newyorkensis]
MVRQGDIIKINLNPKQGHEQQGYRPYICLSHRLVSEHANIAIFAPISNTPRSYPLYVPLIDTETTGKVLLDQLVTIDYNA
RKYNYVETVSDHLLNKLLKSVKVIFQKNASSK

Download         Length: 339 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9088.21 Da        Isoelectric Point: 4.1541

>AT266208 WP_036090223.1 NZ_CP113980:1002398-1002640 [Listeria newyorkensis]
MTTVSIKKWGNSKAVRLPNNILNALNIHENDDLSVEVVDNKIILTKTVADLTIEDLFANYQGEPFQSELQDFEPIGDEKW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3N9TRL1

References