Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | graT-NpoA/HigB(toxin) |
| Location | 4736341..4737500 | Replicon | chromosome |
| Accession | NZ_CP113975 | ||
| Organism | Flavobacterium marginilacus strain IMCC34673 | ||
Toxin (Protein)
| Gene name | graT | Uniprot ID | - |
| Locus tag | OZP07_RS19745 | Protein ID | WP_281636445.1 |
| Coordinates | 4736341..4736622 (-) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | NpoA | Uniprot ID | - |
| Locus tag | OZP07_RS19750 | Protein ID | WP_281636446.1 |
| Coordinates | 4736751..4737500 (-) | Length | 250 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OZP07_RS19725 | 4732367..4732837 | - | 471 | WP_281636442.1 | RDD family protein | - |
| OZP07_RS19730 | 4732967..4733428 | - | 462 | WP_281636443.1 | Lrp/AsnC family transcriptional regulator | - |
| OZP07_RS19735 | 4733585..4735909 | + | 2325 | WP_281636444.1 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase | - |
| OZP07_RS19740 | 4736035..4736328 | - | 294 | WP_194641560.1 | HigA family addiction module antitoxin | - |
| OZP07_RS19745 | 4736341..4736622 | - | 282 | WP_281636445.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| OZP07_RS19750 | 4736751..4737500 | - | 750 | WP_281636446.1 | SDR family oxidoreductase | Antitoxin |
| OZP07_RS19755 | 4737573..4737860 | - | 288 | WP_281636447.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| OZP07_RS19760 | 4737983..4739731 | + | 1749 | WP_281636448.1 | ABC transporter ATP-binding protein | - |
| OZP07_RS19765 | 4739856..4740368 | - | 513 | WP_281636449.1 | hypothetical protein | - |
| OZP07_RS19770 | 4740490..4740789 | - | 300 | WP_281636450.1 | hypothetical protein | - |
| OZP07_RS19775 | 4740882..4741304 | - | 423 | WP_281636451.1 | PIN domain-containing protein | - |
| OZP07_RS19780 | 4741304..4741552 | - | 249 | WP_194641552.1 | DUF6364 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10979.44 Da Isoelectric Point: 10.0926
>T266207 WP_281636445.1 NZ_CP113975:c4736622-4736341 [Flavobacterium marginilacus]
VIKNFGDKETEKVWNGIQSRKLPSEIQNVARRKLRMINNAQNVTDLRIPPANHLEKLSGNFSGLYSIRINNQWRIIFNWE
NDNAFEVQIIDYH
VIKNFGDKETEKVWNGIQSRKLPSEIQNVARRKLRMINNAQNVTDLRIPPANHLEKLSGNFSGLYSIRINNQWRIIFNWE
NDNAFEVQIIDYH
Download Length: 282 bp
Antitoxin
Download Length: 250 a.a. Molecular weight: 26079.58 Da Isoelectric Point: 5.0965
>AT266207 WP_281636446.1 NZ_CP113975:c4737500-4736751 [Flavobacterium marginilacus]
MKKLQNKVAVITGGNSGIGLATAKLFAEEGAKVAITGRNKATIDEAVYEIANGSIGLVSDVSDIQNIDRTYTTIKDTFGK
IDVLVVNAGVFIAAPLADFTEEMFDQTSDINFKGVFFTIQKALPHLNDGASVVITASTVAHKGFATTAAYSASKAAVRSL
ARTLSAELLDRNIRVNVLSPGPIDTPIFSRNGASEEEANGTKTHFASGIPAKRLGTSEEMAAGFLYLASDDSKFMIGGEL
LLDGGAATL
MKKLQNKVAVITGGNSGIGLATAKLFAEEGAKVAITGRNKATIDEAVYEIANGSIGLVSDVSDIQNIDRTYTTIKDTFGK
IDVLVVNAGVFIAAPLADFTEEMFDQTSDINFKGVFFTIQKALPHLNDGASVVITASTVAHKGFATTAAYSASKAAVRSL
ARTLSAELLDRNIRVNVLSPGPIDTPIFSRNGASEEEANGTKTHFASGIPAKRLGTSEEMAAGFLYLASDDSKFMIGGEL
LLDGGAATL
Download Length: 750 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|