Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2957267..2958525 Replicon chromosome
Accession NZ_CP113974
Organism Pseudomonas aeruginosa strain M6A146

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag OZ175_RS13830 Protein ID WP_003112528.1
Coordinates 2957267..2958022 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag OZ175_RS13835 Protein ID WP_003086329.1
Coordinates 2958157..2958525 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OZ175_RS13820 (OZ175_13820) 2952440..2954983 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
OZ175_RS13825 (OZ175_13825) 2955138..2956499 - 1362 WP_073647918.1 DNA recombination protein RmuC -
OZ175_RS13830 (OZ175_13830) 2957267..2958022 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
OZ175_RS13835 (OZ175_13835) 2958157..2958525 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
OZ175_RS13840 (OZ175_13840) 2958598..2959884 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
OZ175_RS13845 (OZ175_13845) 2959940..2961528 - 1589 Protein_2741 aldehyde dehydrogenase family protein -
OZ175_RS13850 (OZ175_13850) 2961607..2962083 + 477 WP_003112531.1 hypothetical protein -
OZ175_RS13855 (OZ175_13855) 2962086..2962361 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T266203 WP_003112528.1 NZ_CP113974:c2958022-2957267 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT266203 WP_003086329.1 NZ_CP113974:c2958525-2958157 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References