266202

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2032595..2033816 Replicon chromosome
Accession NZ_CP113974
Organism Pseudomonas aeruginosa strain M6A146

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag OZ175_RS09450 Protein ID WP_003102740.1
Coordinates 2033238..2033816 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag OZ175_RS09445 Protein ID WP_003088112.1
Coordinates 2032595..2033149 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OZ175_RS09420 (OZ175_09420) 2028163..2028714 + 552 WP_016253541.1 helix-turn-helix domain-containing protein -
OZ175_RS09425 (OZ175_09425) 2028711..2029109 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
OZ175_RS09430 (OZ175_09430) 2029122..2029445 - 324 WP_003102734.1 multidrug efflux SMR transporter -
OZ175_RS09435 (OZ175_09435) 2029776..2030237 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
OZ175_RS09440 (OZ175_09440) 2030242..2032437 + 2196 Protein_1866 xanthine dehydrogenase family protein molybdopterin-binding subunit -
OZ175_RS09445 (OZ175_09445) 2032595..2033149 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
OZ175_RS09450 (OZ175_09450) 2033238..2033816 + 579 WP_003102740.1 HD domain-containing protein Toxin
OZ175_RS09455 (OZ175_09455) 2033925..2035112 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
OZ175_RS09460 (OZ175_09460) 2035102..2037273 - 2172 WP_003088105.1 type I secretion system permease/ATPase -
OZ175_RS09465 (OZ175_09465) 2037263..2038540 - 1278 WP_061193588.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T266202 WP_003102740.1 NZ_CP113974:2033238-2033816 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT266202 WP_003088112.1 NZ_CP113974:2032595-2033149 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References