266201

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1060736..1061778 Replicon chromosome
Accession NZ_CP113974
Organism Pseudomonas aeruginosa strain M6A146

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag OZ175_RS05245 Protein ID WP_003050248.1
Coordinates 1061203..1061778 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag OZ175_RS05240 Protein ID WP_003050245.1
Coordinates 1060736..1061206 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OZ175_RS05205 (OZ175_05205) 1056126..1057545 - 1420 Protein_1020 TIGR03752 family integrating conjugative element protein -
OZ175_RS05210 (OZ175_05210) 1057535..1058446 - 912 WP_023087298.1 TIGR03749 family integrating conjugative element protein -
OZ175_RS05215 (OZ175_05215) 1058443..1059135 - 693 WP_023087299.1 TIGR03746 family integrating conjugative element protein -
OZ175_RS05220 (OZ175_05220) 1059132..1059530 - 399 WP_003105639.1 TIGR03750 family conjugal transfer protein -
OZ175_RS05225 (OZ175_05225) 1059543..1059902 - 360 WP_021195311.1 TIGR03745 family integrating conjugative element membrane protein -
OZ175_RS05230 (OZ175_05230) 1059919..1060152 - 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
OZ175_RS05235 (OZ175_05235) 1060149..1060532 - 384 WP_023087300.1 RAQPRD family integrative conjugative element protein -
OZ175_RS05240 (OZ175_05240) 1060736..1061206 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
OZ175_RS05245 (OZ175_05245) 1061203..1061778 + 576 WP_003050248.1 PIN domain-containing protein Toxin
OZ175_RS05250 (OZ175_05250) 1061796..1062710 + 915 WP_023087301.1 AAA family ATPase -
OZ175_RS05255 (OZ175_05255) 1062707..1063177 + 471 WP_023087302.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
OZ175_RS05260 (OZ175_05260) 1063174..1063674 + 501 WP_003050262.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
OZ175_RS05265 (OZ175_05265) 1063674..1064576 + 903 WP_023087303.1 CBASS oligonucleotide cyclase -
OZ175_RS05270 (OZ175_05270) 1064613..1065338 + 726 WP_023087304.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 992049..1107265 115216


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21630.76 Da        Isoelectric Point: 5.6130

>T266201 WP_003050248.1 NZ_CP113974:1061203-1061778 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT266201 WP_003050245.1 NZ_CP113974:1060736-1061206 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References