266198

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 1418062..1418700 Replicon chromosome
Accession NZ_CP113973
Organism Paenibacillus polymyxa strain P3

Toxin (Protein)


Gene name pemK Uniprot ID H6CFY1
Locus tag OYT09_RS06410 Protein ID WP_007429335.1
Coordinates 1418350..1418700 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID H6CFY0
Locus tag OYT09_RS06405 Protein ID WP_007429334.1
Coordinates 1418062..1418343 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OYT09_RS06385 (OYT09_06390) 1413392..1414384 - 993 WP_272640114.1 ABC transporter substrate-binding protein -
OYT09_RS06390 (OYT09_06395) 1414619..1414936 + 318 Protein_1223 LysE family transporter -
OYT09_RS06395 (OYT09_06400) 1415037..1416314 + 1278 WP_272640115.1 DUF4367 domain-containing protein -
OYT09_RS06400 (OYT09_06405) 1416572..1417768 + 1197 WP_272640116.1 alanine racemase -
OYT09_RS06405 (OYT09_06410) 1418062..1418343 + 282 WP_007429334.1 ribbon-helix-helix protein, CopG family Antitoxin
OYT09_RS06410 (OYT09_06415) 1418350..1418700 + 351 WP_007429335.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OYT09_RS06415 (OYT09_06420) 1418880..1421102 + 2223 WP_272640863.1 Tex family protein -
OYT09_RS06420 (OYT09_06425) 1421207..1421341 - 135 WP_007429337.1 cortex morphogenetic protein CmpA -
OYT09_RS06425 (OYT09_06430) 1421486..1421998 + 513 WP_272640117.1 SprT family protein -
OYT09_RS06440 (OYT09_06445) 1422388..1423263 - 876 WP_272640118.1 Cof-type HAD-IIB family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12822.77 Da        Isoelectric Point: 5.6195

>T266198 WP_007429335.1 NZ_CP113973:1418350-1418700 [Paenibacillus polymyxa]
MIVKRGDVFFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAATHGFDRDSVVLLEQI
RTIDKQRLTDKITHLDEETMRKVSDSLQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10636.25 Da        Isoelectric Point: 8.5257

>AT266198 WP_007429334.1 NZ_CP113973:1418062-1418343 [Paenibacillus polymyxa]
MANLQNTKRIMISLPDHLLQEVDGIVAMENSNRSEFIRQAMKLYVGERKKRYIREAMQRGYMEMAKINLTMASEAFHAEE
DANSTLGRTVSGV

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H6CFY1

Antitoxin

Source ID Structure
AlphaFold DB H6CFY0

References