Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1717530..1718049 Replicon chromosome
Accession NZ_CP113954
Organism Streptococcus gallolyticus strain XH2168

Toxin (Protein)


Gene name relE Uniprot ID F5WVW3
Locus tag OIY87_RS08610 Protein ID WP_012962242.1
Coordinates 1717530..1717808 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F5WVW4
Locus tag OIY87_RS08615 Protein ID WP_012962243.1
Coordinates 1717801..1718049 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIY87_RS08585 (OIY87_09900) 1712847..1713455 - 609 WP_009854651.1 VTT domain-containing protein -
OIY87_RS08590 (OIY87_09905) 1713703..1714005 - 303 WP_009854652.1 PepSY domain-containing protein -
OIY87_RS08595 (OIY87_09910) 1714248..1715780 - 1533 WP_269724885.1 HAMP domain-containing sensor histidine kinase -
OIY87_RS08600 (OIY87_09915) 1715725..1716451 - 727 Protein_1633 response regulator transcription factor -
OIY87_RS08605 (OIY87_09920) 1716523..1717401 - 879 WP_012962241.1 DUF3114 domain-containing protein -
OIY87_RS08610 (OIY87_09925) 1717530..1717808 - 279 WP_012962242.1 type II toxin-antitoxin system YafQ family toxin Toxin
OIY87_RS08615 (OIY87_09930) 1717801..1718049 - 249 WP_012962243.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OIY87_RS08620 (OIY87_09935) 1718377..1718895 + 519 WP_009854658.1 TetR/AcrR family transcriptional regulator -
OIY87_RS08625 (OIY87_09940) 1719009..1720778 + 1770 Protein_1638 oleate hydratase -
OIY87_RS08630 (OIY87_09945) 1720908..1721732 - 825 WP_269725230.1 class C sortase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(2-80)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 11043.84 Da        Isoelectric Point: 9.3104

>T266196 WP_012962242.1 NZ_CP113954:c1717808-1717530 [Streptococcus gallolyticus]
MLKIKYHRQFKRDYKLALKRGLKASKLEEVLEILIKGESLPEKYRDHQLVASKYYQNVRECHIQPDWLLIYQIDDDNLIL
NLVRTGSHSDLF

Download         Length: 279 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9204.69 Da        Isoelectric Point: 4.3193

>AT266196 WP_012962243.1 NZ_CP113954:c1718049-1717801 [Streptococcus gallolyticus]
MTTITFKVDDEMKKEATELYKSMGLDLSSALRLFIKQSLVTRSIPFVIKADELTPVLDDVVKGVNMSEEFTDVKSLMESL
DA

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F5WVW3

Antitoxin

Source ID Structure
AlphaFold DB F5WVW4

References