Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1588521..1589101 Replicon chromosome
Accession NZ_CP113954
Organism Streptococcus gallolyticus strain XH2168

Toxin (Protein)


Gene name hicA Uniprot ID F5WVJ0
Locus tag OIY87_RS07995 Protein ID WP_009854536.1
Coordinates 1588913..1589101 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OIY87_RS07990 Protein ID WP_009854535.1
Coordinates 1588521..1588901 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIY87_RS07985 (OIY87_09300) 1586277..1586693 - 417 WP_269724858.1 nucleoside-diphosphate kinase -
OIY87_RS07990 (OIY87_09305) 1588521..1588901 - 381 WP_009854535.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OIY87_RS07995 (OIY87_09310) 1588913..1589101 - 189 WP_009854536.1 type II toxin-antitoxin system HicA family toxin Toxin
OIY87_RS08000 (OIY87_09315) 1589197..1589862 - 666 WP_172855736.1 type II-A CRISPR-associated protein Csn2 -
OIY87_RS08005 (OIY87_09320) 1589849..1590193 - 345 WP_009854538.1 CRISPR-associated endonuclease Cas2 -
OIY87_RS08010 (OIY87_09325) 1590190..1591056 - 867 WP_009854539.1 type II CRISPR-associated endonuclease Cas1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-62)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-108)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6837.25 Da        Isoelectric Point: 10.8207

>T266195 WP_009854536.1 NZ_CP113954:c1589101-1588913 [Streptococcus gallolyticus]
VPLTGRELAKLAVLKGWKEVRVKGSHHQFKKDGVPYILTIPIHGNKVLGVGLEKKILKDIGL

Download         Length: 189 bp

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 14141.02 Da        Isoelectric Point: 4.2393

>AT266195 WP_009854535.1 NZ_CP113954:c1588901-1588521 [Streptococcus gallolyticus]
MLKSYPAIFHKEDDGSFWVEFPGFGGGTEGDDVEEAMKNAREMLESSLAAYLDEGLELPKVVNMSELSVEDGFITLIQAD
PSPYLKSTKAIRKNVTVPEWLVRLADRENVNYSEVLTQALEKKLQL

Download         Length: 381 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S5WDX8

Antitoxin

Source ID Structure

References