266194

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/-
Location 1352472..1353565 Replicon chromosome
Accession NZ_CP113954
Organism Streptococcus gallolyticus strain XH2168

Toxin (Protein)


Gene name MNTss Uniprot ID R3JIN1
Locus tag OIY87_RS06840 Protein ID WP_000233000.1
Coordinates 1352472..1353341 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag OIY87_RS06845 Protein ID WP_044720927.1
Coordinates 1353356..1353565 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIY87_RS06810 (OIY87_08125) 1347576..1348247 - 672 WP_044720945.1 Rep family protein -
OIY87_RS06815 (OIY87_08130) 1348839..1349246 - 408 WP_235809127.1 hypothetical protein -
OIY87_RS06820 (OIY87_08135) 1349675..1350412 - 738 WP_002321849.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
OIY87_RS06825 (OIY87_08140) 1350537..1350620 - 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
OIY87_RS06830 (OIY87_08145) 1350861..1351724 - 864 WP_002294505.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
OIY87_RS06835 (OIY87_08150) 1351757..1352491 - 735 WP_000662263.1 class I SAM-dependent methyltransferase -
OIY87_RS06840 (OIY87_08155) 1352472..1353341 - 870 WP_000233000.1 nucleotidyltransferase domain-containing protein Toxin
OIY87_RS06845 (OIY87_08160) 1353356..1353565 - 210 WP_044720927.1 helix-turn-helix transcriptional regulator Antitoxin
OIY87_RS06850 (OIY87_08165) 1353887..1354690 - 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
OIY87_RS06855 (OIY87_08170) 1354744..1356228 - 1485 WP_044720925.1 ABC-F type ribosomal protection protein Lsa(E) -
OIY87_RS06860 (OIY87_08175) 1356720..1358282 - 1563 WP_269725228.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island tet(L) / tet(O/W/32/O) / erm(B) / ant(6)-Ia / lnu(B) / lsa(E) - 1331070..1361006 29936
- inside IScluster/Tn tet(L) / tet(O/W/32/O) / erm(B) / ant(6)-Ia / lnu(B) / lsa(E) - 1341473..1356228 14755


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(2-52)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32926.57 Da        Isoelectric Point: 4.8781

>T266194 WP_000233000.1 NZ_CP113954:c1353341-1352472 [Streptococcus gallolyticus]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7832.08 Da        Isoelectric Point: 4.7228

>AT266194 WP_044720927.1 NZ_CP113954:c1353565-1353356 [Streptococcus gallolyticus]
MIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 210 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3JIN1

Antitoxin

Source ID Structure

References