Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/YoeB-RelB
Location 1109144..1109660 Replicon chromosome
Accession NZ_CP113954
Organism Streptococcus gallolyticus strain XH2168

Toxin (Protein)


Gene name Txe Uniprot ID F5X0X3
Locus tag OIY87_RS05630 Protein ID WP_014620143.1
Coordinates 1109144..1109401 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID F5X0X4
Locus tag OIY87_RS05635 Protein ID WP_012961966.1
Coordinates 1109394..1109660 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIY87_RS05605 (OIY87_06920) 1104410..1105108 + 699 WP_077496826.1 GntR family transcriptional regulator -
OIY87_RS05610 (OIY87_06925) 1105421..1106269 - 849 WP_269724775.1 MurR/RpiR family transcriptional regulator -
OIY87_RS05615 (OIY87_06930) 1106439..1107422 + 984 WP_269724776.1 Gfo/Idh/MocA family oxidoreductase -
OIY87_RS05620 (OIY87_06935) 1107427..1107951 + 525 WP_269724777.1 heme-binding protein -
OIY87_RS05625 (OIY87_06940) 1107972..1109030 + 1059 WP_269724778.1 Gfo/Idh/MocA family oxidoreductase -
OIY87_RS05630 (OIY87_06945) 1109144..1109401 - 258 WP_014620143.1 Txe/YoeB family addiction module toxin Toxin
OIY87_RS05635 (OIY87_06950) 1109394..1109660 - 267 WP_012961966.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OIY87_RS05640 (OIY87_06955) 1109824..1110156 + 333 WP_061100436.1 putative DNA-binding protein -
OIY87_RS05645 (OIY87_06960) 1110227..1111792 + 1566 WP_269724779.1 signal recognition particle protein -
OIY87_RS05650 (OIY87_06965) 1111858..1112874 - 1017 WP_077496840.1 AraC family transcriptional regulator -
OIY87_RS05655 (OIY87_06970) 1113048..1114289 + 1242 WP_269724780.1 ABC transporter ATP-binding protein -
OIY87_RS05660 (OIY87_06975) 1114286..1114489 + 204 WP_269724781.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1105722..1161681 55959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10277.64 Da        Isoelectric Point: 8.7825

>T266193 WP_014620143.1 NZ_CP113954:c1109401-1109144 [Streptococcus gallolyticus]
MIKAWSDDAWNDYMYWYNQGNKATIKKINRLIKEIDRTPFTGIGKPEPLKHDLSGKWSRRITDEHRLIYSVDETTIYFYS
CKDHY

Download         Length: 258 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10365.60 Da        Isoelectric Point: 4.6290

>AT266193 WP_012961966.1 NZ_CP113954:c1109660-1109394 [Streptococcus gallolyticus]
MEAVAYSNFRQNLKHYMKQVNDDAEPLIVTSKNIDDTVVVLSKRDYDSMQETFRIMSNNYLMNKIKRGDEQFKAANFQTH
ELLEVDDD

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S5WCL9

Antitoxin

Source ID Structure
AlphaFold DB A0A1S5WCN9

References