Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 641563..642049 Replicon chromosome
Accession NZ_CP113954
Organism Streptococcus gallolyticus strain XH2168

Toxin (Protein)


Gene name relE Uniprot ID A0A1S5WAV3
Locus tag OIY87_RS03475 Protein ID WP_009853752.1
Coordinates 641780..642049 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F5WZP8
Locus tag OIY87_RS03470 Protein ID WP_013642845.1
Coordinates 641563..641790 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIY87_RS03450 (OIY87_04755) 637695..638009 + 315 WP_003063779.1 metalloregulator ArsR/SmtB family transcription factor -
OIY87_RS03455 (OIY87_04760) 638012..639895 + 1884 WP_269725183.1 heavy metal translocating P-type ATPase -
OIY87_RS03460 (OIY87_04765) 640055..640375 + 321 WP_061458966.1 multidrug efflux SMR transporter -
OIY87_RS03465 (OIY87_04770) 640592..641284 + 693 WP_009853732.1 phosphoglycerate mutase -
OIY87_RS03470 (OIY87_04775) 641563..641790 + 228 WP_013642845.1 DUF6290 family protein Antitoxin
OIY87_RS03475 (OIY87_04780) 641780..642049 + 270 WP_009853752.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OIY87_RS03480 (OIY87_04785) 642428..642994 - 567 WP_234756076.1 DUF3267 domain-containing protein -
OIY87_RS03485 (OIY87_04790) 643243..643764 + 522 WP_009853754.1 transcription repressor NadR -
OIY87_RS03490 (OIY87_04795) 643961..644515 + 555 WP_234756074.1 hypothetical protein -
OIY87_RS03495 (OIY87_04800) 644670..646823 + 2154 WP_009853756.1 penicillin-binding protein PBP2B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10554.64 Da        Isoelectric Point: 10.4700

>T266192 WP_009853752.1 NZ_CP113954:641780-642049 [Streptococcus gallolyticus]
MTYRLVVSDKVKKQLKKMDKHVRLMLAKDMKKHLDGLENPRQIGKALIGQFKGLWRYRIGNYRVICDIMDDELVILAIEI
GHRKDIYKN

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8732.81 Da        Isoelectric Point: 4.3239

>AT266192 WP_013642845.1 NZ_CP113954:641563-641790 [Streptococcus gallolyticus]
MSIVSLRLNEKEEELFRSYSIHTGKTLSELFKTALAEQIEDQLDYETGIKALKEFKKNPVTHSIDDIIEEFENDL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S5WAV3

Antitoxin

Source ID Structure
AlphaFold DB A0A1S5WAU8

References