266183

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09907-MazE
Location 1486636..1487234 Replicon chromosome
Accession NZ_CP113943
Organism Lactobacillus sp. ESL0681

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag OZX59_RS07090 Protein ID WP_277125613.1
Coordinates 1486893..1487234 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag OZX59_RS07085 Protein ID WP_277125612.1
Coordinates 1486636..1486899 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OZX59_RS07055 (OZX59_07055) 1481662..1481922 + 261 WP_277125601.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
OZX59_RS07060 (OZX59_07060) 1481926..1482192 + 267 WP_277125603.1 type II toxin-antitoxin system YafQ family toxin -
OZX59_RS07065 (OZX59_07065) 1482427..1483269 + 843 WP_277125605.1 hypothetical protein -
OZX59_RS07070 (OZX59_07070) 1483515..1484000 + 486 WP_277125606.1 sigma-70 family RNA polymerase sigma factor -
OZX59_RS07075 (OZX59_07075) 1484123..1485337 + 1215 WP_277125608.1 SLAP domain-containing protein -
OZX59_RS07080 (OZX59_07080) 1485373..1486512 + 1140 WP_277125611.1 SLAP domain-containing protein -
OZX59_RS07085 (OZX59_07085) 1486636..1486899 + 264 WP_277125612.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
OZX59_RS07090 (OZX59_07090) 1486893..1487234 + 342 WP_277125613.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OZX59_RS07095 (OZX59_07095) 1487267..1487506 - 240 WP_277125615.1 hypothetical protein -
OZX59_RS07100 (OZX59_07100) 1487865..1488869 + 1005 WP_277125617.1 tryptophan ABC transporter substrate-binding protein -
OZX59_RS07105 (OZX59_07105) 1488866..1489768 + 903 WP_277125619.1 ABC transporter permease -
OZX59_RS07110 (OZX59_07110) 1489758..1490525 + 768 WP_277125621.1 ATP-binding cassette domain-containing protein -
OZX59_RS07115 (OZX59_07115) 1490655..1491257 - 603 WP_277125623.1 zeta toxin family protein -
OZX59_RS07120 (OZX59_07120) 1491254..1491454 - 201 WP_277125625.1 hypothetical protein -
OZX59_RS07125 (OZX59_07125) 1491717..1491998 + 282 WP_277125628.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-101)

Antitoxin

SpoVT-AbrB domain

(12-52)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12779.67 Da        Isoelectric Point: 6.7234

>T266183 WP_277125613.1 NZ_CP113943:1486893-1487234 [Lactobacillus sp. ESL0681]
MVKQGDIFYVDFKPSKGHEQINRRPAIALSHDLVQATSNMTIVAPISSTQRNFPMYHTLTSSQNVYGKVLLDQTIALDLQ
ARSITQNSIVDRVSKAELIEIIELYKLLFTVDE

Download         Length: 342 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9963.18 Da        Isoelectric Point: 6.2195

>AT266183 WP_277125612.1 NZ_CP113943:1486636-1486899 [Lactobacillus sp. ESL0681]
MTAIIGKTRIAQWGNSKATRIPNNIVKQLHLKENQSLTITLKDNSIVLTPEEKQPKNIHELFANWQDDGQRAEELDWGTS
SGHELEW

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References