Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/DinJ(antitoxin) |
| Location | 368577..369457 | Replicon | chromosome |
| Accession | NZ_CP113913 | ||
| Organism | Bifidobacterium sp. ESL0800 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | OZX75_RS01525 | Protein ID | WP_277146500.1 |
| Coordinates | 368948..369457 (+) | Length | 170 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | OZX75_RS01520 | Protein ID | WP_277146499.1 |
| Coordinates | 368577..368951 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OZX75_RS01490 (OZX75_01490) | 363923..364747 | + | 825 | WP_277147581.1 | ABC transporter permease | - |
| OZX75_RS01495 (OZX75_01495) | 364855..365643 | + | 789 | WP_277146494.1 | ABC transporter ATP-binding protein | - |
| OZX75_RS01500 (OZX75_01500) | 365636..366442 | + | 807 | WP_277146495.1 | dipeptide/oligopeptide/nickel ABC transporter ATP-binding protein | - |
| OZX75_RS01505 (OZX75_01505) | 366451..367443 | - | 993 | WP_277146496.1 | NAD(P)-dependent oxidoreductase | - |
| OZX75_RS01510 (OZX75_01510) | 367555..367758 | - | 204 | WP_277146497.1 | helix-turn-helix transcriptional regulator | - |
| OZX75_RS01515 (OZX75_01515) | 367745..368239 | - | 495 | WP_277146498.1 | hypothetical protein | - |
| OZX75_RS01520 (OZX75_01520) | 368577..368951 | + | 375 | WP_277146499.1 | damage-inducible protein J | Antitoxin |
| OZX75_RS01525 (OZX75_01525) | 368948..369457 | + | 510 | WP_277146500.1 | PIN domain-containing protein | Toxin |
| OZX75_RS01530 (OZX75_01530) | 369555..370178 | + | 624 | WP_277146501.1 | isochorismatase family protein | - |
| OZX75_RS01535 (OZX75_01535) | 370230..372386 | + | 2157 | WP_277146502.1 | DNA helicase RecQ | - |
| OZX75_RS01540 (OZX75_01540) | 372471..372941 | + | 471 | WP_277146503.1 | ASCH domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 170 a.a. Molecular weight: 18601.39 Da Isoelectric Point: 4.6126
>T266152 WP_277146500.1 NZ_CP113913:368948-369457 [Bifidobacterium sp. ESL0800]
MIKGTKHNIVFDTNILIDIVMHRSLRESAALKLMDACADLNLNPMCVSLSLKDVDYIVKVNTKREFKDAMAGVEQATVQQ
LVAQIGWNSVQSIIEVCEVAAVDGEVCKNALKLRSAHPDYEDDLIIAAARQAGADMVVTGDQDLIRHFPDLCVSVEDALK
RIDGDDFKS
MIKGTKHNIVFDTNILIDIVMHRSLRESAALKLMDACADLNLNPMCVSLSLKDVDYIVKVNTKREFKDAMAGVEQATVQQ
LVAQIGWNSVQSIIEVCEVAAVDGEVCKNALKLRSAHPDYEDDLIIAAARQAGADMVVTGDQDLIRHFPDLCVSVEDALK
RIDGDDFKS
Download Length: 510 bp
Antitoxin
Download Length: 125 a.a. Molecular weight: 14260.14 Da Isoelectric Point: 4.4773
>AT266152 WP_277146499.1 NZ_CP113913:368577-368951 [Bifidobacterium sp. ESL0800]
MTMVQMNIRIDADLKDEVDEILKRIGKTPSSVIRELWDFIQDSGEIPDLDTAAEKKDRELEKRKKLQKIDNMSGVVPRTL
QDMGLIGRGDDPFKSMSAKELHDYADEQRYEDYIRESVAESVAV
MTMVQMNIRIDADLKDEVDEILKRIGKTPSSVIRELWDFIQDSGEIPDLDTAAEKKDRELEKRKKLQKIDNMSGVVPRTL
QDMGLIGRGDDPFKSMSAKELHDYADEQRYEDYIRESVAESVAV
Download Length: 375 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|