Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 5287739..5288280 Replicon chromosome
Accession NZ_CP113910
Organism Streptomyces sp. KMM 9044

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HUV60_RS23780 Protein ID WP_257849240.1
Coordinates 5287739..5288002 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag HUV60_RS23785 Protein ID WP_164493698.1
Coordinates 5287999..5288280 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUV60_RS23750 (HUV60_023770) 5283642..5283949 + 308 Protein_4677 CU044_5270 family protein -
HUV60_RS23755 (HUV60_023775) 5283987..5284814 - 828 WP_269441231.1 transposase family protein -
HUV60_RS23760 (HUV60_023780) 5285157..5285456 + 300 WP_173313100.1 hypothetical protein -
HUV60_RS23765 (HUV60_023785) 5285453..5285965 + 513 WP_257849237.1 hypothetical protein -
HUV60_RS23770 (HUV60_023790) 5286135..5286266 - 132 WP_257849238.1 hypothetical protein -
HUV60_RS23775 (HUV60_023795) 5286280..5286636 - 357 WP_257849239.1 DUF5911 domain-containing protein -
HUV60_RS23780 (HUV60_023800) 5287739..5288002 - 264 WP_257849240.1 Txe/YoeB family addiction module toxin Toxin
HUV60_RS23785 (HUV60_023805) 5287999..5288280 - 282 WP_164493698.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HUV60_RS23790 (HUV60_023810) 5288628..5288780 + 153 Protein_4685 transposase -
HUV60_RS23795 (HUV60_023815) 5288841..5289782 - 942 Protein_4686 IS3 family transposase -
HUV60_RS23800 (HUV60_023820) 5290048..5290659 - 612 WP_257849241.1 ANTAR domain-containing protein -
HUV60_RS23805 (HUV60_023825) 5290937..5291974 - 1038 WP_257849242.1 rod shape-determining protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 5270028..5289782 19754
- inside Genomic island - - 5278823..5289782 10959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10446.81 Da        Isoelectric Point: 8.0720

>T266151 WP_257849240.1 NZ_CP113910:c5288002-5287739 [Streptomyces sp. KMM 9044]
VKVLFVDDGWNDYLWWQGNDRKILKRINQLIADIDRGGHEGIGKPEPLRNDLSGYWSRRINSEHRLVYRIDENTIIHVVA
CRFHYER

Download         Length: 264 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10156.38 Da        Isoelectric Point: 4.2158

>AT266151 WP_164493698.1 NZ_CP113910:c5288280-5287999 [Streptomyces sp. KMM 9044]
MKTMSVTELRAGIADALDAVENDAEELVITRTGHEPMVVVSLAEYEALKETDYLLRSPAMAERLRRSIEQDRAGQGALRE
LVDPDDEAGRGAA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References