Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5467552..5468078 Replicon chromosome
Accession NZ_CP113904
Organism Klebsiella michiganensis strain PS_Koxy4

Toxin (Protein)


Gene name relE Uniprot ID A0A7R6HXL1
Locus tag F0A14_RS25835 Protein ID WP_015572079.1
Coordinates 5467791..5468078 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag F0A14_RS25830 Protein ID WP_000534858.1
Coordinates 5467552..5467791 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0A14_RS25810 (F0A14_025810) 5463021..5463836 - 816 WP_004118130.1 SDR family oxidoreductase -
F0A14_RS25815 (F0A14_025815) 5464228..5465955 + 1728 WP_182094697.1 ATP-binding protein -
F0A14_RS25820 (F0A14_025820) 5465952..5467367 + 1416 WP_182094696.1 AAA family ATPase -
F0A14_RS25825 (F0A14_025825) 5467416..5467527 - 112 Protein_5076 hypothetical protein -
F0A14_RS25830 (F0A14_025830) 5467552..5467791 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
F0A14_RS25835 (F0A14_025835) 5467791..5468078 + 288 WP_015572079.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F0A14_RS25840 (F0A14_025840) 5468195..5468722 + 528 WP_259347316.1 hypothetical protein -
F0A14_RS25845 (F0A14_025845) 5469223..5469600 - 378 WP_182094695.1 acetyltransferase -
F0A14_RS25850 (F0A14_025850) 5469597..5472455 - 2859 WP_182094694.1 conjugative transfer ATPase -
F0A14_RS25855 (F0A14_025855) 5472455..5472865 - 411 WP_006785978.1 TIGR03751 family conjugal transfer lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5409845..5498435 88590


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11209.09 Da        Isoelectric Point: 10.0714

>T266147 WP_015572079.1 NZ_CP113904:5467791-5468078 [Klebsiella michiganensis]
MAYFLDFDERALKEWRKLGSTVREQLKNKLAEVLESPRIDANKLRGMHDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT266147 WP_000534858.1 NZ_CP113904:5467552-5467791 [Klebsiella michiganensis]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References