26614

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2155150..2155664 Replicon chromosome
Accession NC_017338
Organism Staphylococcus aureus subsp. aureus JKD6159

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag SAA6159_RS10790 Protein ID WP_000581792.1
Coordinates 2155150..2155359 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag SAA6159_RS10795 Protein ID WP_000138934.1
Coordinates 2155371..2155664 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAA6159_RS10770 2150658..2152016 - 1359 WP_000611476.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
SAA6159_RS10775 2152031..2153101 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
SAA6159_RS10780 2153419..2154621 + 1203 WP_001109939.1 rod shape-determining protein RodA -
SAA6159_RS10785 2154885..2155022 - 138 WP_000828354.1 hypothetical protein -
SAA6159_RS10790 2155150..2155359 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
SAA6159_RS10795 2155371..2155664 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
SAA6159_RS10800 2155830..2157314 + 1485 WP_000571545.1 cardiolipin synthase -
SAA6159_RS10805 2157342..2157989 + 648 WP_001187622.1 HD domain-containing protein -
SAA6159_RS10810 2158738..2159610 - 873 WP_000725802.1 membrane protein insertase YidC -
SAA6159_RS10815 2159696..2160337 - 642 WP_000483146.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T26614 WP_000581792.1 NC_017338:c2155359-2155150 [Staphylococcus aureus subsp. aureus JKD6159]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T26614 NC_017338:c2155359-2155150 [Staphylococcus aureus subsp. aureus JKD6159]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT26614 WP_000138934.1 NC_017338:c2155664-2155371 [Staphylococcus aureus subsp. aureus JKD6159]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT26614 NC_017338:c2155664-2155371 [Staphylococcus aureus subsp. aureus JKD6159]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References