266139

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 876239..876896 Replicon chromosome
Accession NZ_CP113904
Organism Klebsiella michiganensis strain PS_Koxy4

Toxin (Protein)


Gene name cptA Uniprot ID J5U333
Locus tag F0A14_RS04225 Protein ID WP_004854060.1
Coordinates 876486..876896 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag F0A14_RS04220 Protein ID WP_004124953.1
Coordinates 876239..876505 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F0A14_RS04205 (F0A14_004210) 871473..871898 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
F0A14_RS04210 (F0A14_004215) 872019..874817 - 2799 WP_049079129.1 transcriptional regulator DagR -
F0A14_RS04215 (F0A14_004220) 875011..875994 - 984 WP_014226793.1 tRNA-modifying protein YgfZ -
F0A14_RS04220 (F0A14_004225) 876239..876505 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
F0A14_RS04225 (F0A14_004230) 876486..876896 + 411 WP_004854060.1 protein YgfX Toxin
F0A14_RS04230 (F0A14_004235) 876905..877426 - 522 WP_143440241.1 flavodoxin FldB -
F0A14_RS04235 (F0A14_004240) 877548..878444 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
F0A14_RS04240 (F0A14_004245) 878467..879180 + 714 WP_004854054.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
F0A14_RS04245 (F0A14_004250) 879186..880919 + 1734 WP_182095148.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16106.97 Da        Isoelectric Point: 10.9455

>T266139 WP_004854060.1 NZ_CP113904:876486-876896 [Klebsiella michiganensis]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT266139 WP_004124953.1 NZ_CP113904:876239-876505 [Klebsiella michiganensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References