266083

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 2557572..2558258 Replicon chromosome
Accession NZ_CP113831
Organism Enterococcus faecalis strain T30

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag OZE10_RS13100 Protein ID WP_128722476.1
Coordinates 2557914..2558258 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag OZE10_RS13095 Protein ID WP_010707137.1
Coordinates 2557572..2557895 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OZE10_RS13035 (2552745) 2552745..2553941 - 1197 WP_128722493.1 DEAD/DEAH box helicase -
OZE10_RS13040 (2553931) 2553931..2554224 - 294 WP_002418647.1 VRR-NUC domain-containing protein -
OZE10_RS13045 (2554227) 2554227..2554910 - 684 WP_128722477.1 DUF1642 domain-containing protein -
OZE10_RS13050 (2555022) 2555022..2555216 - 195 WP_010716255.1 hypothetical protein -
OZE10_RS13055 (2555217) 2555217..2555390 - 174 WP_010773396.1 hypothetical protein -
OZE10_RS13060 (2555396) 2555396..2555596 - 201 WP_002407633.1 hypothetical protein -
OZE10_RS13065 (2555634) 2555634..2555903 - 270 WP_002365131.1 hypothetical protein -
OZE10_RS13070 (2555979) 2555979..2556293 + 315 WP_002385638.1 hypothetical protein -
OZE10_RS13075 (2556274) 2556274..2556402 - 129 WP_002385637.1 hypothetical protein -
OZE10_RS13080 (2556418) 2556418..2556594 - 177 WP_002385636.1 helix-turn-helix transcriptional regulator -
OZE10_RS13085 (2556678) 2556678..2557061 + 384 WP_002385635.1 DUF2513 domain-containing protein -
OZE10_RS13090 (2557058) 2557058..2557267 - 210 WP_002415277.1 DUF2829 domain-containing protein -
OZE10_RS13095 (2557572) 2557572..2557895 + 324 WP_010707137.1 helix-turn-helix transcriptional regulator Antitoxin
OZE10_RS13100 (2557914) 2557914..2558258 + 345 WP_128722476.1 ImmA/IrrE family metallo-endopeptidase Toxin
OZE10_RS13105 (2558344) 2558344..2558940 + 597 WP_033781504.1 DUF4352 domain-containing protein -
OZE10_RS13110 (2559117) 2559117..2560298 + 1182 WP_113813754.1 site-specific integrase -
OZE10_RS13115 (2560401) 2560401..2560550 - 150 WP_002356321.1 50S ribosomal protein L33 -
OZE10_RS13120 (2560676) 2560676..2562814 - 2139 WP_024041710.1 penicillin-binding transpeptidase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2483783..2560298 76515


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(22-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-59)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13670.65 Da        Isoelectric Point: 5.6183

>T266083 WP_128722476.1 NZ_CP113831:2557914-2558258 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRAYFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMALYKIPVFRSKMESEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEIYLK

Download         Length: 345 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12278.84 Da        Isoelectric Point: 5.2423

>AT266083 WP_010707137.1 NZ_CP113831:2557572-2557895 [Enterococcus faecalis]
MTVFDRVKKLADSQKISIVELEEKLNFSRNSLYAWKKSKPSIDKLEAVANYFGVSTDYLLGREVSNKSKQSDDLDDVLDN
VMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References