Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1216225..1217766 Replicon chromosome
Accession NZ_CP113808
Organism Shewanella sp. DAU305

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OX890_RS05295 Protein ID WP_268650205.1
Coordinates 1216465..1217766 (+) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OX890_RS05290 Protein ID WP_220591948.1
Coordinates 1216225..1216461 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OX890_RS05270 (OX890_05270) 1211246..1212235 + 990 WP_268650595.1 LysR family transcriptional regulator -
OX890_RS05275 (OX890_05275) 1212237..1213604 - 1368 WP_268650204.1 MATE family efflux transporter -
OX890_RS05280 (OX890_05280) 1213829..1214119 + 291 WP_006086113.1 co-chaperone GroES -
OX890_RS05285 (OX890_05285) 1214177..1215814 + 1638 WP_012196636.1 chaperonin GroEL -
OX890_RS05290 (OX890_05290) 1216225..1216461 + 237 WP_220591948.1 helix-turn-helix domain-containing protein Antitoxin
OX890_RS05295 (OX890_05295) 1216465..1217766 + 1302 WP_268650205.1 HipA domain-containing protein Toxin
OX890_RS05300 (OX890_05300) 1217864..1218538 + 675 WP_268650206.1 HNH endonuclease -
OX890_RS05305 (OX890_05305) 1219297..1219872 + 576 WP_268650207.1 hypothetical protein -
OX890_RS05310 (OX890_05310) 1219989..1220375 + 387 WP_219253638.1 carboxymuconolactone decarboxylase family protein -
OX890_RS05315 (OX890_05315) 1220534..1220785 - 252 WP_268650208.1 DUF2999 family protein -
OX890_RS05320 (OX890_05320) 1220952..1222448 + 1497 WP_268650209.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48590.87 Da        Isoelectric Point: 5.8621

>T266070 WP_268650205.1 NZ_CP113808:1216465-1217766 [Shewanella sp. DAU305]
MSTSKKLTLEMHLGDLIIGELSFDATTDTFAVHYTKHWQQSGFPLSPTIPLDGTGSSSQISMFLVNLLPENKGLDYLIES
LGVSKGNTFALIRAIGLDTAGAVAFVPKGTLLPETQLRPIKAEEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYN
GEEFAFAEGALSSTHIVKFEKYRHLVLNEFMTMRLAKAIGMNVANVDIVHFGDYKVLCVERFDRRYMPNEQRVLRRHIVD
SCQALGFSVSKKYERNFGSGRDVKDIREGVSFNRLFSLAVKCRNPVAAKQDMLQWALFNLLTGNADAHGKNYSFFMTPSG
MEPTPWYDLVSVAMYEDFEQQLAMAIDDEFDPNSIYAYQLAAFIDGLGLPRNLLISNLTSIAQRIPQAIAEVVSMLPALD
ESETVFVAHYKAQLLARCDRYLSFAAEVRDVKV

Download         Length: 1302 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8485.82 Da        Isoelectric Point: 6.2232

>AT266070 WP_220591948.1 NZ_CP113808:1216225-1216461 [Shewanella sp. DAU305]
MASPLNQQSLGLLIKERRKSAALTQDVAAMLCGVTKKTLIRVEKGEDVYISTVFKILDGLGIDIVAAQTSDTETNGWY

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References