Detailed information of TA system TA026607

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1941626..1942402
• Replicon: chromosome
• Accession: NC_017338
• Organism: Staphylococcus aureus subsp. aureus JKD6159

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: SAA6159_RS09500
• Protein ID: WP_000031108.1
• Coordinates: 1941626..1941778 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: SAA6159_RS09505
• Protein ID: WP_001251216.1
• Coordinates: 1941803..1942402 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAA6159_RS09475	1937588..1938409	+	822	WP_000669379.1	RluA family pseudouridine synthase	-
SAA6159_RS09480	1938873..1940258	-	1386	WP_000116242.1	class II fumarate hydratase	-
SAA6159_RS09485	1940454..1940849	-	396	WP_000901024.1	hypothetical protein	-
SAA6159_RS09500	1941626..1941778	-	153	WP_000031108.1	hypothetical protein	Toxin
SAA6159_RS09505	1941803..1942402	-	600	WP_001251216.1	glucosamine-6-phosphate isomerase	Antitoxin
SAA6159_RS09510	1942561..1943031	-	471	WP_000181397.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
SAA6159_RS09515	1943036..1944163	-	1128	WP_000379992.1	tRNA epoxyqueuosine(34) reductase QueG	-
SAA6159_RS09520	1944314..1945036	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
SAA6159_RS09525	1945029..1946486	-	1458	WP_000649909.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (126-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T26607 WP_000031108.1 NC_017338:c1941778-1941626 [Staphylococcus aureus subsp. aureus JKD6159]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T26607 NC_017338:c1941778-1941626 [Staphylococcus aureus subsp. aureus JKD6159]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAGAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22371.53 Da
• Isoelectric Point: 5.1445

>AT26607 WP_001251216.1 NC_017338:c1942402-1941803 [Staphylococcus aureus subsp. aureus JKD6159]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGI
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT26607 NC_017338:c1942402-1941803 [Staphylococcus aureus subsp. aureus JKD6159]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTATA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTCTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Toxin

• AlphaFold DB: X5E2E6