Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 924345..925933 Replicon chromosome
Accession NZ_CP113808
Organism Shewanella sp. DAU305

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OX890_RS04090 Protein ID WP_126491018.1
Coordinates 924626..925933 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OX890_RS04085 Protein ID WP_126491017.1
Coordinates 924345..924626 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OX890_RS04060 (OX890_04060) 919454..919810 - 357 WP_268650140.1 hypothetical protein -
OX890_RS04065 (OX890_04065) 919976..920875 - 900 WP_268650141.1 LysR family transcriptional regulator -
OX890_RS04070 (OX890_04070) 921116..921853 + 738 WP_268650588.1 pyrimidine 5'-nucleotidase -
OX890_RS04075 (OX890_04075) 921888..922526 - 639 WP_126491015.1 ERCC4 domain-containing protein -
OX890_RS04080 (OX890_04080) 922873..923841 + 969 WP_268650589.1 hypothetical protein -
OX890_RS04085 (OX890_04085) 924345..924626 + 282 WP_126491017.1 helix-turn-helix domain-containing protein Antitoxin
OX890_RS04090 (OX890_04090) 924626..925933 + 1308 WP_126491018.1 type II toxin-antitoxin system HipA family toxin Toxin
OX890_RS04095 (OX890_04095) 926207..926530 - 324 WP_126491019.1 hypothetical protein -
OX890_RS04100 (OX890_04100) 926677..927540 - 864 WP_006086670.1 YicC/YloC family endoribonuclease -
OX890_RS04105 (OX890_04105) 927951..928664 + 714 WP_006079862.1 ribonuclease PH -
OX890_RS04110 (OX890_04110) 928841..929482 + 642 WP_006086671.1 orotate phosphoribosyltransferase -
OX890_RS04115 (OX890_04115) 929709..930359 - 651 WP_006079864.1 GTP cyclohydrolase I FolE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 48603.14 Da        Isoelectric Point: 7.5317

>T266069 WP_126491018.1 NZ_CP113808:924626-925933 [Shewanella sp. DAU305]
MAVLDVYMNGYLVGELTKSSTGSHQFAYAQQWLAIPGSRPISLSMPLRKQAYKGDEVYNFFDNLLPDNHEVKNRVVARHN
ADSTQAFDLLAKIGQDSVGALQLVPHGQPPFDTKKIESKPLSDKQLEKVLKGYQSNIPLGMLADDDDFRISIAGAQEKTA
LLKLNGEWRLPIKSTPTTHIIKLPIGEINSHSHSIDMSDSVENEYLCMMIVREFGLDAPQCSIIKVGDIKALAVERFDRR
LSSDGTWIMRLPQEDFCQALNIPPAKKYESLGGPGIEQIMPYLLGSMNSERDRYNFIKSQVLFWLLAATDGHAKNFSLFI
EADGGYRLTPFYDILSMYPVIGGKGLNIRDAKLAMGLKAAKGKKYQINQIFPRHFILTAKAVGFDTGIMMEMMRDIADKV
EAVVVKVKAQLPDDFPPHIQDSILNGLTDRIKRIA

Download         Length: 1308 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10713.16 Da        Isoelectric Point: 7.0147

>AT266069 WP_126491017.1 NZ_CP113808:924345-924626 [Shewanella sp. DAU305]
MKVTNAKQLSTYLKDARLNAQLSQSKVASKVGIRQDTVSSFELNPDSTKLETLFKILSALNLELDIKVRNLQLVDERRHD
NATVPEQEWKEEW

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References