Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2816857..2818445 Replicon chromosome
Accession NZ_CP113789
Organism Klebsiella variicola subsp. tropica strain BSK_177V2

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OUI59_RS13960 Protein ID WP_074385880.1
Coordinates 2816857..2818179 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MCN9
Locus tag OUI59_RS13965 Protein ID WP_008804920.1
Coordinates 2818179..2818445 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OUI59_RS13945 (OUI59_13945) 2811922..2814423 + 2502 WP_268657089.1 fimbria/pilus outer membrane usher protein -
OUI59_RS13950 (OUI59_13950) 2814411..2815415 + 1005 WP_268657090.1 fimbrial protein -
OUI59_RS13955 (OUI59_13955) 2815548..2816840 + 1293 WP_061154620.1 glycoside hydrolase family 10 protein -
OUI59_RS13960 (OUI59_13960) 2816857..2818179 - 1323 WP_074385880.1 type II toxin-antitoxin system HipA family toxin Toxin
OUI59_RS13965 (OUI59_13965) 2818179..2818445 - 267 WP_008804920.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OUI59_RS13970 (OUI59_13970) 2818711..2819037 - 327 WP_100729694.1 hydroxyisourate hydrolase -
OUI59_RS13975 (OUI59_13975) 2819034..2819534 - 501 WP_074385882.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OUI59_RS13980 (OUI59_13980) 2819512..2820891 - 1380 WP_074385883.1 nucleobase:cation symporter-2 family protein -
OUI59_RS13985 (OUI59_13985) 2821237..2822391 + 1155 WP_061154625.1 FAD-dependent urate hydroxylase HpxO -
OUI59_RS13990 (OUI59_13990) 2822372..2823295 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49182.58 Da        Isoelectric Point: 7.9110

>T266053 WP_074385880.1 NZ_CP113789:c2818179-2816857 [Klebsiella variicola subsp. tropica]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRDAFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKTVNFPREQMLAILHEFAERVP
QAIESARRTLPADFSAHVWRAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.30 Da        Isoelectric Point: 8.5912

>AT266053 WP_008804920.1 NZ_CP113789:c2818445-2818179 [Klebsiella variicola subsp. tropica]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MCN9

References