Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1858043..1858633 Replicon chromosome
Accession NZ_CP113789
Organism Klebsiella variicola subsp. tropica strain BSK_177V2

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag OUI59_RS09090 Protein ID WP_074385360.1
Coordinates 1858301..1858633 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag OUI59_RS09085 Protein ID WP_074385359.1
Coordinates 1858043..1858300 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OUI59_RS09075 (OUI59_09075) 1857351..1857544 + 194 Protein_1777 hypothetical protein -
OUI59_RS09080 (OUI59_09080) 1857571..1857642 + 72 Protein_1778 cell morphology transcriptional regulator XreR2 -
OUI59_RS09085 (OUI59_09085) 1858043..1858300 + 258 WP_074385359.1 antitoxin Antitoxin
OUI59_RS09090 (OUI59_09090) 1858301..1858633 + 333 WP_074385360.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OUI59_RS09100 (OUI59_09100) 1858956..1860392 + 1437 WP_165784170.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
OUI59_RS09110 (OUI59_09110) 1860898..1861200 - 303 WP_061153979.1 XRE family transcriptional regulator -
OUI59_RS09115 (OUI59_09115) 1861205..1861558 - 354 WP_074385362.1 type II toxin-antitoxin system RelE/ParE family toxin -
OUI59_RS09120 (OUI59_09120) 1862125..1862322 + 198 WP_074385363.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11904.78 Da        Isoelectric Point: 10.1840

>T266047 WP_074385360.1 NZ_CP113789:1858301-1858633 [Klebsiella variicola subsp. tropica]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGHFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDAVINEVLARLDAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9486.00 Da        Isoelectric Point: 4.4929

>AT266047 WP_074385359.1 NZ_CP113789:1858043-1858300 [Klebsiella variicola subsp. tropica]
MYKTRLKRVGGSIMLAVPPAVLKALELSTDSEVGMTIDNGCLIIEPQKRPHYSLEELLAQCDPRAEMSEEDREWIDAPAV
GKEIM

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References