Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1717334..1717965 Replicon chromosome
Accession NZ_CP113789
Organism Klebsiella variicola subsp. tropica strain BSK_177V2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OUI59_RS08520 Protein ID WP_074387014.1
Coordinates 1717690..1717965 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OUI59_RS08515 Protein ID WP_022066422.1
Coordinates 1717334..1717693 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OUI59_RS08490 (OUI59_08490) 1713591..1714535 + 945 WP_074387017.1 nickel ABC transporter permease subunit NikB -
OUI59_RS08495 (OUI59_08495) 1714532..1715365 + 834 WP_074387016.1 nickel ABC transporter permease subunit NikC -
OUI59_RS08500 (OUI59_08500) 1715365..1716129 + 765 WP_023340796.1 nickel import ATP-binding protein NikD -
OUI59_RS08505 (OUI59_08505) 1716126..1716917 + 792 WP_074387015.1 nickel import ATP-binding protein NikE -
OUI59_RS08510 (OUI59_08510) 1716905..1717306 + 402 WP_048330886.1 nickel-responsive transcriptional regulator NikR -
OUI59_RS08515 (OUI59_08515) 1717334..1717693 - 360 WP_022066422.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OUI59_RS08520 (OUI59_08520) 1717690..1717965 - 276 WP_074387014.1 type II toxin-antitoxin system HicA family toxin Toxin
OUI59_RS08525 (OUI59_08525) 1718362..1719375 + 1014 WP_074387013.1 magnesium transporter -
OUI59_RS08530 (OUI59_08530) 1719415..1720608 - 1194 WP_074387012.1 NAD(P)/FAD-dependent oxidoreductase -
OUI59_RS08535 (OUI59_08535) 1720839..1722335 + 1497 WP_061153045.1 inorganic phosphate transporter PitA -
OUI59_RS08540 (OUI59_08540) 1722396..1722731 - 336 WP_061153044.1 universal stress protein UspB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10265.88 Da        Isoelectric Point: 10.3165

>T266046 WP_074387014.1 NZ_CP113789:c1717965-1717690 [Klebsiella variicola subsp. tropica]
MDQQVLSLRNKQRHTLEQLFKIPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13294.99 Da        Isoelectric Point: 4.4605

>AT266046 WP_022066422.1 NZ_CP113789:c1717693-1717334 [Klebsiella variicola subsp. tropica]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCHEAGIEPYAHPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References